Academic Journal
Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide
| العنوان: | Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide |
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| المؤلفون: | Kamegawa, Akiko, Hiroaki, Yoko, Tani, Kazutoshi, Fujiyoshi, Yoshinori |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2016 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Letters |
| الوصف: | Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain. We determined the structure of aquaporin-4 in the presence of AZA using electron crystallography. Most of the features of the 5- A ˚ density map were consistent with those of the previously determined atomic model. The map showed a protruding density from near the extracellular pore entrance, which most likely represents the bound AZA. Molecular docking simulations supported the location of the protrusion as the likely AZA-binding site. These findings suggest that AZA reduces water conduction by obstructing the pathway at the extracellular entrance without inducing a large conformational change in the protein. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://jmicro.oxfordjournals.org/cgi/content/short/65/2/177; http://dx.doi.org/10.1093/jmicro/dfv368 |
| DOI: | 10.1093/jmicro/dfv368 |
| الاتاحة: | http://jmicro.oxfordjournals.org/cgi/content/short/65/2/177 https://doi.org/10.1093/jmicro/dfv368 |
| Rights: | Copyright (C) 2016, Japanese Society of Microscopy |
| رقم الانضمام: | edsbas.8708488E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jmicro/dfv368 |
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