التفاصيل البيبلوغرافية
| العنوان: |
JCB: ARTICLE An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function |
| المؤلفون: |
Radhakrishnan Narayanan, Marilyn Leonard, Byeong Doo Song, Ra L. Schmid, Mani Ramaswami |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/39/c4/J_Cell_Biol_2005_Apr_11_169(1)_117-126.tar.gz |
| المجموعة: |
CiteSeerX |
| الوصف: |
he mechanism by which the self-assembling GTPase dynamin functions in vesicle formation remains controversial. Point mutations in shibire, the Drosophila dynamin, cause temperature-sensitive (ts) defects in endocytosis. We show that the ts2 mutation, which occurs in the switch 2 region of dynamin’s GTPase domain, compromises GTP binding affinity. Three second-site suppressor mutations, one in the switch 1 region of the GTPase domain and two in the GTPase effector domain (GED), dynamin’s putative GAP, fully rescue the shits2 T defects in synaptic vesicle recycling. The functional rescue in vivo |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.2107 |
| الاتاحة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.2107 |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.86F8A41C |
| قاعدة البيانات: |
BASE |