Academic Journal
Effects of Escherichia coli strain Nissle 1917 on exercise-induced disruption of gastrointestinal integrity
| العنوان: | Effects of Escherichia coli strain Nissle 1917 on exercise-induced disruption of gastrointestinal integrity |
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| المؤلفون: | Mooren, Frank, Maleki, B. H., Pilat, C., Ringseis, R., Eder, K., Teschler, M., Krüger, K. |
| المصدر: | http://lobid.org/resources/99370676492306441#!, 120(7):1591-1599. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Adolescent [MeSH], Antioxidants/pharmacology [MeSH], Adult [MeSH], Humans [MeSH], Gastrointestinal tract, Gastrointestinal Tract/physiology [MeSH], Gastrointestinal Tract/microbiology [MeSH], Probiotic, Exercise/physiology [MeSH], Original Article, Exercise, Oxidative Stress/physiology [MeSH], Male [MeSH], Young Adult [MeSH], Probiotics/pharmacology [MeSH], Escherichia coli/pathogenicity [MeSH], Intestinal fatty acid binding protein |
| الوصف: | Purpose!#!The aim of the current study was to investigate the effects of the probiotic Escherichia coli strain Nissle 1917 (EcN) on the exercise-induced disruption of gastrointestinal (GI) integrity and the associated release of damage and inflammatory markers.!##!Methods!#!After a pre-performance test, 19 untrained subjects (aged 18-35 years) passed two identical exhaustive treadmill exercise tests in an intensity corresponding to 60-80% VO!##!Results!#!The intake of EcN resulted in a significantly lower increase in I-FABP and TBARS after exercise (p < 0.05). In contrast, no effect of EcN supplementation was found for hsCRP and leucocyte numbers. Similarly, no differences were found for levels of zonulin and claudin-3. Exercise-associated GI complaints were not affected by the probiotic supplement.!##!Conclusion!#!The probiotic EcN reduced the exercise-associated increase in oxidative stress. This antioxidative mechanism probably leads to a reduction of GI epithelial damage after exhaustive exercise. The lack of EcN effects on other markers of GI permeability and systemic inflammation is most likely due to an inadequate exercise load, with rather small and insignificant exercise effects on these parameters. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6467630; https://doi.org/10.1007/s00421-020-04382-w; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295722/ |
| DOI: | 10.1007/s00421-020-04382-w |
| الاتاحة: | https://repository.publisso.de/resource/frl:6467630 https://doi.org/10.1007/s00421-020-04382-w https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295722/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.86F60789 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00421-020-04382-w |
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