Academic Journal
Effects of ECE-1b rs213045 and rs2038089 polymorphisms on the development of contrast-induced acute kidney injury in patients with acute coronary syndrome
| العنوان: | Effects of ECE-1b rs213045 and rs2038089 polymorphisms on the development of contrast-induced acute kidney injury in patients with acute coronary syndrome |
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| المؤلفون: | Dalgic, Sadiye Nur, Yilmaz Aydogan, Hulya, Ozturk, Oguz, Pence, Sadrettin, Kanca Demirci, Deniz, Abaci, Okay, Kocas, Cuneyt, Dalgic, Yalcin, Bostan, Cem, Yildiz, Ahmet |
| المصدر: | Journal of International Medical Research ; volume 48, issue 3, page 030006051988698 ; ISSN 0300-0605 1473-2300 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2019 |
| الوصف: | Objective Endothelin-1 (ET-1) promotes the progression and induction of sclerotic renal changes in end-stage kidney disease. Membrane-bound endothelin-converting enzyme 1 (ECE-1) is involved in the production of ET-1. The aim of this study was to assess the effects of ECE-1b rs213045 and rs2038089 polymorphisms, which have been shown to be involved in the development of atherosclerosis, hypertension, and nephropathy, on the development of contrast-induced acute kidney injury (CI-AKI) in patients with acute coronary syndrome. Methods Our study included 38 patients with CI-AKI (CI-AKI[+]) and 55 patients without CI-AKI (CI-AKI[−]) who had coronary syndrome. The ECE-1b polymorphisms rs213045 and rs2038089 were assessed using real-time PCR. Serum ET-1 levels were measured by ELISA. Results The distributions of ECE-1b rs213045 and rs2038089 polymorphisms were similar between the two groups. Additionally, the serum ET-1 level did not different between the groups and was not associated with the ECE-1b polymorphisms. Peri-procedural low systolic blood pressure (SBP) was identified as a risk factor for CI-AKI development. Conclusion Our findings indicate that ECE-1b rs213045 and rs2038089 polymorphisms are not associated with CI-AKI development and that peri-procedural low SBP is a risk factor for CI-AKI. However, variations in ECE-1b rs2038089 may contribute to the development of CI-AKI. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0300060519886987 |
| الاتاحة: | http://dx.doi.org/10.1177/0300060519886987 http://journals.sagepub.com/doi/pdf/10.1177/0300060519886987 http://journals.sagepub.com/doi/full-xml/10.1177/0300060519886987 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.86D9923E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0300060519886987 |
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