Academic Journal
Sonodynamic therapy reduces iron retention of hemorrhagic plaque
| العنوان: | Sonodynamic therapy reduces iron retention of hemorrhagic plaque |
|---|---|
| المؤلفون: | Li, Bicheng, Gong, Jie, Sheng, Siqi, Lu, Minqiao, Guo, Shuyuan, Yao, Jianting, Zhang, Haiyu, Zhao, Xuezhu, Cao, Zhengyu, Sun, Xin, Wang, Huan, Cao, Yang, Jiang, Yongxing, Tian, Zhen, Liu, Bin, Zhao, Hua, Zhang, Zhiguo, Jin, Hong, Tian, Ye |
| المساهمون: | National Key Scientific Instrument and Equipment Development Projects of China |
| المصدر: | Bioengineering & Translational Medicine ; volume 6, issue 1 ; ISSN 2380-6761 2380-6761 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Intraplaque hemorrhage (IPH) plays a major role in the aggressive progression of vulnerable plaque, leading to acute cardiovascular events. We previously demonstrated that sonodynamic therapy (SDT) inhibits atherosclerotic plaque progression. In this study, we investigated whether SDT could also be applied to treat more advanced hemorrhagic plaque and addressed the underlying mechanism. SDT decreased atherosclerotic burden, positively altered atherosclerotic lesion composition, and alleviated iron retention in rabbit hemorrhagic plaques. Furthermore, SDT reduced iron retention by stimulating ferroportin 1 (Fpn1) expression in apolipoprotein E ( ApoE ) −/− mouse plaques with high susceptibility to IPH. Subsequently, SDT inhibited iron‐overload‐induced foam‐cell formation and pro‐inflammatory cytokines secretion in vitro. Moreover, SDT reduced levels of the labile iron pool and ferritin expression via the reactive oxygen species (ROS)‐nuclear factor erythroid 2‐related factor 2 (Nrf2)‐FPN1 pathway. SDT exerted therapeutic effects on hemorrhagic plaques and reduced iron retention via the ROS‐Nrf2‐FPN1 pathway in macrophages, thereby suggesting that it is a potential translational strategy for patients with advanced atherosclerosis in clinical practice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/btm2.10193 |
| الاتاحة: | http://dx.doi.org/10.1002/btm2.10193 https://onlinelibrary.wiley.com/doi/pdf/10.1002/btm2.10193 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/btm2.10193 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.86CDF6D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/btm2.10193 |
|---|