Academic Journal
Neuroprotective effects of trigonelline in kainic acid-induced epilepsy: Behavioral, biochemical, and functional insights
| العنوان: | Neuroprotective effects of trigonelline in kainic acid-induced epilepsy: Behavioral, biochemical, and functional insights |
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| المؤلفون: | Faizan, M, Jahan, I, Ishaq, M, Alhalmi, A, Khan, RM, Noman, OM, Hasson, S, Mothana, RA |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Liverpool John Moores University: LJMU Research Online |
| مصطلحات موضوعية: | RM Therapeutics. Pharmacology, RS Pharmacy and materia medica |
| الوصف: | Trigonelline, an alkaloid found in the seeds of Trigonella foenum-graecum L. (fenugreek), has been recognized for its potential in treating various diseases. Notably, trigonelline has demonstrated a neuroprotective impact by reducing intrasynaptosomal calcium levels, inhibiting the production of reactive oxygen species (ROS), and regulating cytokines. Kainic acid, an agonist of kainic acid receptors, is utilized for inducing temporal lobe epilepsy and is a common choice for establishing kainic acid-induced status epilepticus, a widely used epileptic model. The neuroprotective effect of trigonelline in the context of kainic acid-induced epilepsy remains unexplored. This study aimed to induce epilepsy by administering kainic acid (10 mg/kg, single subcutaneous dose) and subsequently evaluate the potential anti-epileptic effect of trigonelline (100 mg/kg, intraperitoneal administration for 14 days). Ethosuccimide (ETX) (187.5 mg/kg) served as the standard drug for comparison. The anti-epileptic effect of trigonelline over a 14-day administration period was examined. Behavioral assessments, such as the Novel Object Recognition (NOR) test, Open Field Test (OFT), and Plus Maze tests, were conducted 2 h after kainic acid administration to investigate spatial and non-spatial acquisition abilities in rats. Additionally, biochemical analysis encompassing intrasynaptosomal calcium levels, LDH activity, serotonin levels, oxidative indicators, and inflammatory cytokines associated with inflammation were evaluated. Trigonelline exhibited significant behavioral improvements by reducing anxiety in open field and plus maze tests, along with an amelioration of memory impairment. Notably, trigonelline substantially lowered intrasynaptosomal calcium levels and LDH activity, indicating its neuroprotective effect by mitigating cytotoxicity and neuronal injury within the hippocampus tissue. Moreover, trigonelline demonstrated a remarkable reduction in inflammatory cytokines and oxidative stress indicators. In summary, this study ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://researchonline.ljmu.ac.uk/id/eprint/21775/1/Neuroprotective%20effects%20of%20trigonelline%20in%20kainic%20acid-induced%20epilepsy.pdf; Faizan, M, Jahan, I, Ishaq, M, Alhalmi, A, Khan, RM, Noman, OM, Hasson, S and Mothana, RA (2023) Neuroprotective effects of trigonelline in kainic acid-induced epilepsy: Behavioral, biochemical, and functional insights. Saudi Pharmaceutical Journal, 31 (12). ISSN 1319-0164 |
| DOI: | 10.1016/j.jsps.2023.101843 |
| الاتاحة: | http://researchonline.ljmu.ac.uk/id/eprint/21775/ https://researchonline.ljmu.ac.uk/id/eprint/21775/1/Neuroprotective%20effects%20of%20trigonelline%20in%20kainic%20acid-induced%20epilepsy.pdf https://doi.org/10.1016/j.jsps.2023.101843 |
| Rights: | cc_by |
| رقم الانضمام: | edsbas.8697C0D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jsps.2023.101843 |
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