Academic Journal
Vitamin D affects the neutrophil‐to‐lymphocyte ratio in patients with type 2 diabetes mellitus
| العنوان: | Vitamin D affects the neutrophil‐to‐lymphocyte ratio in patients with type 2 diabetes mellitus |
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| المؤلفون: | Wang, Si‐Yang, Shen, Ting‐Ting, Xi, Bei‐Li, Shen, Zhan, Zhang, Xian |
| المصدر: | Journal of Diabetes Investigation ; volume 12, issue 2, page 254-265 ; ISSN 2040-1116 2040-1124 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aims/Introduction Chronic inflammation is an underlying feature of type 2 diabetes mellitus. Hypovitaminosis D is associated with type 2 diabetes mellitus, but whether it contributes to chronic inflammation is unclear. We examined the effects of vitamin D on various immune markers to evaluate its contribution to systemic inflammation in type 2 diabetes mellitus. Materials and Methods We retrospectively analyzed data from type 2 diabetes mellitus patients, people with prediabetes and control patients without diabetes ( n = 9,746). Demographic and clinical variables were evaluated using descriptive statistics and generalized linear regression. A stratified analysis based on total serum vitamin D was also carried out. Results Neutrophil count was a significant predictor of 1,5‐anhydroglucitol and glycated hemoglobin (HbA1c) in patients with prediabetes (1,5‐anhydroglucitol: β = −0.719, P < 0.001 and HbA1c: β = −0.006, P = 0.002) and patients with diabetes (1,5‐anhydroglucitol: β = 0.207, P = 0.004 and HbA1c: β = −0.067, P = 0.010). Lymphocyte count was a significant predictor of HbA1c in patients without diabetes (β = 0.056, P < 0.001) and patients with prediabetes (β = 0.038, P < 0.001). The neutrophil‐to‐lymphocyte ratio (NLR) was a significant predictor of HbA1c in patients without diabetes (β = −0.001, P = 0.032). No immune markers differed significantly based on vitamin D level among patients without diabetes ( P > 0.05 for all). Among patients with prediabetes, those who were vitamin D‐deficient had the highest NLR ( P = 0.040). Among patients with diabetes, those who were vitamin D‐deficient had the highest neutrophil count ( P = 0.001), lowest lymphocyte count ( P = 0.016) and highest NLR ( P < 0.001). Conclusions The NLR is strongly influenced by serum vitamin D level. Given the high prevalence of hypovitaminosis D and elevated NLR among chronic disease patients and the elderly, our results suggest that clinical interpretation of NLR as a predictive marker of type 2 diabetes ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/jdi.13338 |
| الاتاحة: | http://dx.doi.org/10.1111/jdi.13338 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjdi.13338 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdi.13338 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jdi.13338 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.8669D67B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jdi.13338 |
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