التفاصيل البيبلوغرافية
| العنوان: |
Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. |
| المؤلفون: |
Lo Sasso, G, Ryu, D, Mouchiroud, L, Fernando, SC, Anderson, CL, Katsyuba, E, Piersigilli, A, Hottiger, MO, Schoonjans, K, Auwerx, J |
| المساهمون: |
Papa, S |
| بيانات النشر: |
Public Library of Science (PLoS) |
| سنة النشر: |
2014 |
| المجموعة: |
The University of Melbourne: Digital Repository |
| الوصف: |
Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. Mice with an intestinal specific Sirt1 deficiency (Sirt1int-/-) have more Paneth and goblet cells with a consequent rearrangement of the gut microbiota. From a mechanistic point of view, the effects on mouse intestinal cell maturation are mediated by SIRT1-dependent changes in the acetylation status of SPDEF, a master regulator of Paneth and goblet cells. Our results suggest that targeting SIRT1 may be of interest in the management of IBD and CAC. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
1932-6203 |
| Relation: |
pii: PONE-D-14-21101; Lo Sasso, G., Ryu, D., Mouchiroud, L., Fernando, S. C., Anderson, C. L., Katsyuba, E., Piersigilli, A., Hottiger, M. O., Schoonjans, K. & Auwerx, J. (2014). Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. PLoS One, 9 (7), pp.e102495-. https://doi.org/10.1371/journal.pone.0102495.; http://hdl.handle.net/11343/304423 |
| الاتاحة: |
http://hdl.handle.net/11343/304423 |
| Rights: |
CC BY ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: |
edsbas.8668D85F |
| قاعدة البيانات: |
BASE |
Full Text Finder