Academic Journal
Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents
| العنوان: | Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents |
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| المؤلفون: | Alvaradejo, Gabriela Gil, Nguyen, Hung V.-T., Harvey, Peter, Gallagher, Nolan M., Le, Dao, Ottaviani, M. Francesca, Jasanoff, Alan, Delaittre, Guillaume, Johnson, Jeremiah A. |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2019 |
| المجموعة: | University of Nottingham: Repository@Nottingham |
| الوصف: | Copyright © 2019 American Chemical Society. The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-defined norbornene-terminated poly(2-ethyl-2-oxazoline) (PEtOx) macromonomers (MM) were prepared by cationic ring-opening polymerization. ROMP of these MMs produced bottlebrush copolymers with PEtOx side chains. In addition, PEtOx-based branched MMs bearing a terminal alkyne group were prepared and conjugated to an azide-containing bis-spirocyclohexyl nitroxide via Cu-catalyzed azide-alkyne cycloaddition (CuAAC). ROMP of this branched MM, followed by in situ cross-linking, provided PEtOx-based brush-arm star polymers (BASPs) with nitroxide radicals localized at the core-shell interface. These PEtOx-based nitroxide-containing BASPs displayed relaxivity values on par with state-of-the-art polyethylene glycol (PEG)-based nitroxide materials, making them promising as organic radical contrast agents for metal-free magnetic resonance imaging (MRI). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://nottingham-repository.worktribe.com/output/2828753; ACS Macro Letters; Volume 8; Issue 4; Pagination 473-478 |
| DOI: | 10.1021/acsmacrolett.9b00016 |
| الاتاحة: | https://doi.org/10.1021/acsmacrolett.9b00016 https://nottingham-repository.worktribe.com/file/2828753/1/PHarvey%20ACSMacroLett%202828753 https://nottingham-repository.worktribe.com/output/2828753 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.86557BA3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsmacrolett.9b00016 |
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