Academic Journal
NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment
| العنوان: | NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a novel environment |
|---|---|
| المؤلفون: | Hirano, Tetsushi, Yanai, Shogo, Takada, Tadashi, Yoneda, Naoki, Omotehara, Takuya, Kubota, Naoto, Minami, Kiichi, Yamamoto, Anzu, Mantani, Youhei, Yokoyama, Toshifumi, Kitagawa, Hiroshi, Hoshi, Nobuhiko |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | Kobe University Repository (Kernel) / 神戸大学学術成果リポジトリ |
| مصطلحات موضوعية: | Neonicotinoid, Clothianidin, Neurobehavioral effect, Elevated plus-maze test, Anxiety-related behavior, Human-audible vocalization |
| الوصف: | Neonicotinoids are novel systemic pesticides acting as agonists on the nicotinic acetylcholine receptors (nAChRs) of insects. Experimental studies have revealed that neonicotinoids pose potential risks for the nervous systems of non-target species, but the brain regions responsible for their behavioral effects remain incompletely understood. This study aimed to assess the neurobehavioral effects of clothianidin (CTD), a later neonicotinoid developed in 2001 and widely used worldwide, and to explore the target regions of neonicotinoids in the mammalian brain. A single-administration of 5 or 50 mg/kg CTD to male C57BL/6N mice at or below the no-observed-adverse-effect level (NOAEL) induced an acute increase in anxiety during the elevated plus-maze test. In addition, mice in the CTD-administered group spontaneously emitted human-audible vocalizations (4–16 kHz), which are behavioral signs of aversive emotions, and showed increased numbers of c-fos immunoreactive cells in the paraventricular thalamic nucleus and dentate gyrus of the hippocampus. In conclusion, mice exposed to NOAEL-dose CTD would be rendered vulnerable to a novel environment via the activation of thalamic and hippocampal regions related to stress responses. These findings should provide critical insight into the neurobehavioral effects of neonicotinoids on mammals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:doi/10.1016/j.toxlet.2017.10.010 |
| الاتاحة: | http://www.lib.kobe-u.ac.jp/handle_kernel/90006385 http://www.lib.kobe-u.ac.jp/repository/90006385.pdf |
| Rights: | © 2018 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.86501993 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |