التفاصيل البيبلوغرافية
| العنوان: |
Outcomes Analyses of Pediatric Acute Liver Failure Subjects listed for Liver Transplantation |
| المؤلفون: |
Kulkarni, Sakil S., Goss, Charles W., Khan, Adeel S., Nadler, Michelle L., Stoll, Janis M., Doyle, Maria B., Turmelle, Yumirle P., Rudnick, David A. |
| المصدر: |
J Pediatr Gastroenterol Nutr |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Article, socio, envir |
| الوصف: |
BACKGROUND: We characterized recent outcomes in US Pediatric Acute Liver Failure (PALF) subjects listed for liver transplantation (LT) using the Scientific Registry of Transplant Recipients (SRTR) database. METHODS: Pediatric subjects listed for LT from 2002–2015 were assigned to the “PALF” group based on status 1/1A listing, INR≥2, no hepatic artery thrombosis, and no primary graft nonfunction (N=397). Subjects were assigned to the “non-PALF” group if listed with any status other than 1/1A (N=4509). RESULTS: The PALF group had more infants < 3 months of age and males at listing for LT compared to the non-PALF group. Two-thirds of PALF subjects had an indeterminate etiology. LT waitlist survival was significantly worse in the PALF group compared to the non-PALF group. Likelihood of removal from the LT waitlist for being “too sick” was higher, while that of removal for “spontaneous recovery” was lower in PALF subjects. Post-LT short term (30 days) and long term (60 months) outcomes were also significantly worse in PALF vs. non-PALF subjects. PALF subjects who underwent living-donor-liver-transplant (LDLT) had similar LT waitlist times and post-LT survival compared to those undergoing deceased-donor-liver-transplant (DDLT). Over the study period, we observed a decreased number of liver transplants, and increase in LT waitlist- and short term post LT-survival in PALF subjects. CONCLUSION: LT waitlist and post-LT outcomes are worse in PALF subjects compared to non-PALF subjects. PALF subjects who undergo LDLT have similar waitlist times and post-LT outcomes compared to those undergoing DDLT. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| Relation: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296584/ |
| الاتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9296584/ |
| Rights: |
undefined |
| رقم الانضمام: |
edsbas.861995C9 |
| قاعدة البيانات: |
BASE |