التفاصيل البيبلوغرافية
| العنوان: |
Characterization of Helicobacter pylori Infection in the upper gastrointestinal tract of twins |
| المؤلفون: |
Vilchez-Vargas, R., Skieceviciene, J., Arstikyte, J., Urba, M., Thon, C., Schanze, D., Zenker, M., Malfertheiner, P., Kupcinskas, J., Link, A. |
| المصدر: |
Helicobacter: Special Issue: The Year in Helicobacter. EHMSG – 33rd International Workshop on Helicobacter & Microbiota in Inflammation & Cancer : Virtual Conference September 10-12, 2020, Glasgow, United Kingdom : Accepted Abstracts / European Helicobacter and Microbiota Study Group ; Guest editors: Francis Mégraud & Peter Malfertheiner, Oxford : Wiley-Blackwell, 2020, vol. 25, suppl. 1, p. 77-78, no. EP6.15 ; ISSN 1083-4389 ; eISSN 1523-5378 |
| سنة النشر: |
2020 |
| المجموعة: |
LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką) |
| مصطلحات موضوعية: |
Gastrointestinal diseases, complications, Helicobacter infections, Helicobacter pylori, Twins, info:eu-repo/classification/udc/616.33/.34 |
| الوصف: |
Introduction: Helicobacter pylori (H. pylori) is an infectious disease that causes chronic gastritis, may contribute to development of preneoplastic mucosal alterations and also leads to development of peptic ulcer disease and gastric cancer. Characterization of microbiota in monozygotic and heterozygotic twins may offer a unique model to understand their contribution to H. pylori induced gastroduodenal pathologies (but is still insufficiently utilized). Methods: In this study, we characterized bacterial communities from saliva of 20 twin pairs, upper GI tract of 25 twin pairs and feces from 99 twin pairs (total 288 samples) by high throughput sequencing. Results: H. pylori was only detected in gastric corpus and antrum mucosa but not in saliva or feces. Among twins with discordant H. pylori status, we observed no correlation between gastric microbiome and the presence of H. pylori infection. However, among the 9 twins with concordant H. pylori positivity, there were 5 twins with the same clone of H. pylori infection while in 4 twins the subspecies were different in comparison to paired twin siblings. Conclusions: Our preliminary results strongly suggest that H. pylori is the most predominant factor that may influence stomach microbiome of the twins. Differences in H. pylori phylotypes suggest that H. pylori might be acquired from heterogeneous source during the childhood and lifetime. Further investigations are being carried out to characterize the microbiome of saliva and the lower GI tract from twins. |
| نوع الوثيقة: |
conference object |
| اللغة: |
English |
| Relation: |
http://lsmu.lvb.lt/LSMU:ELABAPDB69906127&prefLang=en_US |
| الاتاحة: |
http://lsmu.lvb.lt/LSMU:ELABAPDB69906127&prefLang=en_US |
| رقم الانضمام: |
edsbas.860AA5F4 |
| قاعدة البيانات: |
BASE |