Academic Journal
Relationship between Vitamin D3 Deficiency, Metabolic Syndrome and VDR, GC , and CYP2R1 Gene Polymorphisms
| العنوان: | Relationship between Vitamin D3 Deficiency, Metabolic Syndrome and VDR, GC , and CYP2R1 Gene Polymorphisms |
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| المؤلفون: | Carmina Mariana Stroia, Timea Claudia Ghitea, Maria Vrânceanu, Mariana Mureșan, Erika Bimbo-Szuhai, Csaba Robert Pallag, Annamaria Pallag |
| المصدر: | Nutrients, Vol 16, Iss 9, p 1272 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | vitamin D3 supplementation, metabolic syndrome, BMI, overweight, obese, 25(OH)D3, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | The presence of vitamin D3 deficiency associated with the presence of metabolic syndrome (MS) has important public health effects. This study aims to investigate the relationship between vitamin D3 deficiency, MS and vitamin D3 receptor ( VDR ), GC Vitamin D binding protein ( GC ), and cytochrome P450 family 2 subfamily R member 1 ( CYP2R1 ) gene polymorphisms, and genes whose encoded proteins are responsible for vitamin D3 metabolism and transport. A total of 58 participants were included in this study (age 39 ± 12 years) and were selected over a 12-month period. They were divided into four groups, depending on the presence of polymorphisms in VDR , GC , and CYP2R1 genes and their weight status. At baseline, in months 3, 6, and 12, biochemical parameters including 25(OH)D3, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and homeostatic model assessment (HOMA index), the insulin resistance indicator were measured. Our results show that all subjects in the polymorphism group supplemented with vitamin D3 reached an optimal level of vitamin D3 associated with high concentrations of 25(OH)D3. Weight loss was most significant in patients in the POW group (overweight patients). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6643 |
| Relation: | https://www.mdpi.com/2072-6643/16/9/1272; https://doaj.org/toc/2072-6643; https://doaj.org/article/2c7348c9a08f4ae59a35410346ac8a3d |
| DOI: | 10.3390/nu16091272 |
| الاتاحة: | https://doi.org/10.3390/nu16091272 https://doaj.org/article/2c7348c9a08f4ae59a35410346ac8a3d |
| رقم الانضمام: | edsbas.86040047 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726643 |
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| DOI: | 10.3390/nu16091272 |