Academic Journal
Statin use is safe and does not impact prognosis in patient with de novo follicular lymphoma treated with immunochemotherapy: An exploratory analysis of the PRIMA cohort study.
| العنوان: | Statin use is safe and does not impact prognosis in patient with de novo follicular lymphoma treated with immunochemotherapy: An exploratory analysis of the PRIMA cohort study. |
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| المؤلفون: | Bachy, Emmanuel, Estell, Jane A, Van Den Neste, Eric, Bouabdallah, Réda, Bargay, Joan, Delmer, Alain, Gelas-Dore, Bénédicte, Gomes da Silva, Maria, Fitoussi, Olivier, Belada, David, Maisonneuve, Hervé, Intragumtornchai, Tanin, Lamy, Thierry, Dartigues, Peggy, Seymour, John Francis, Salles, Gilles |
| المساهمون: | UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - (SLuc) Service d'hématologie |
| المصدر: | American Journal of Hematology, Vol. 91, no.4, p. 410-415 (2016) |
| بيانات النشر: | JohnWiley & Sons, Inc. |
| سنة النشر: | 2016 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| مصطلحات موضوعية: | Adult, Lymphoma, Follicular, Male, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Proportional Hazards Models, Randomized Controlled Trials as Topic, Treatment Outcome, Aged, Young Adult, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Cohort Studies, Drug Interactions, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| الوصف: | An adverse prognostic impact of statin use in lymphoma was first suspected from in vitro data showing an impairment of anti-CD20 antibody binding. However, further clinical studies suggested an improved outcome associated with their use in hematological malignancies. In particular, a survival benefit was reported for patients with follicular lymphoma on statins. Our objective was to assess the outcome of follicular lymphoma patients treated in the PRIMA study with immunochemotherapy according to the use of statins. Among the 1,217 patients enrolled in the PRIMA study, 1,135 were included in the present study. Concomitant treatments at registration were available for all patients. Among those 1,135 patients, 119 were on statins (10.5%) at diagnosis. Adverse events frequencies, event-free survival (EFS), time to next lymphoma treatment (TTNLT), time to next chemotherapy (TTNCT), and overall survival (OS) were evaluated according to the use of statins. The rates of overall and specific cardiovascular adverse events between the two groups of patients were comparable both during induction and maintenance. Outcome in terms of response rates or EFS, TTNLT, TTNCT, and OS were similar regardless of the use of statins (P = 0.57, P = 0.85, P = 0.30, and P = 0.43, respectively) in univariate analysis and after further adjustments for potential confounding factors in multivariate analysis. In conclusion, statin use does not impact the prognosis of patients with follicular lymphoma treated with immunochemotherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0361-8609 1096-8652 |
| Relation: | boreal:184843; http://hdl.handle.net/2078.1/184843; info:pmid/26799234; urn:ISSN:0361-8609; urn:EISSN:1096-8652 |
| DOI: | 10.1002/ajh.24305 |
| الاتاحة: | http://hdl.handle.net/2078.1/184843 https://doi.org/10.1002/ajh.24305 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.85CC0120 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 03618609 10968652 |
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| DOI: | 10.1002/ajh.24305 |