Academic Journal
Identification of Flavonoids, Antioxidant and Antiproliferative Activity of Aqueous Infusions of Calendula officinalis L., Chelidonium majus L., Teucrium chamaedrys L. and Alchemilla vulgaris L. ; Identifikacija flavonoida, antioksidacijska i antiproliferacijska aktivnost vodenih infuza biljnih vrsta Calendula officinalis L., Chelidonium majus L., Teucrium chamaedrys L. i Alchemilla vulgaris L.
| العنوان: | Identification of Flavonoids, Antioxidant and Antiproliferative Activity of Aqueous Infusions of Calendula officinalis L., Chelidonium majus L., Teucrium chamaedrys L. and Alchemilla vulgaris L. ; Identifikacija flavonoida, antioksidacijska i antiproliferacijska aktivnost vodenih infuza biljnih vrsta Calendula officinalis L., Chelidonium majus L., Teucrium chamaedrys L. i Alchemilla vulgaris L. |
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| المؤلفون: | Bilušić, Tea, Šola, Ivana, Čikeš Čulić, Vedrana |
| المصدر: | Food Technology and Biotechnology ; ISSN 1330-9862 (Print) ; ISSN 1334-2606 (Online) ; Volume 62 ; Issue 1 |
| بيانات النشر: | University of Zagreb Faculty of Food Technology and Biotechnology |
| سنة النشر: | 2024 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | antioxidant activity, antiproliferative activity, Calendula officinalis L., Chelidonium majus L., Teucrium chamaedrys L., Alchemilla vulgaris L, antioksidacijska aktivnost, antiproliferacijska aktivnost |
| الوصف: | Research background. The current changes in the global economy, characterised by the climate crisis and the economic and health impact of the COVID-19 pandemic, have led to a significant demand for medicinal herbs. This trend is expected to increase significantly by 2050. In this study, we investigated the biopotential of aqueous infusions of four medicinal plants: Calendula officinalis, Chelidonium majus, Teucrium chamaedrys and Alchemilla vulgaris. Experimental approach. The flavonoid analysis of the aqueous infusions of the selected plants was carried out using the RP-HPLC technique. The antiproliferative activity of the prepared aqueous plant infusions was analysed against three human cancer cell lines (MDA-MD-231, T24 and A549), while the antioxidant potential was measured using three antioxidant methods (DPPH, FRAP and Rancimat assay). Results and conclusions. T. chamaedrys had the highest total phenolics (expressed as GAE (2061±42) mg/L), free radical scavenging activity (IC50=1.9 mg/mL) and Fe(III) reducing antioxidant power (expressed as FeCl2 (9798±27) mg/L). At a concentration of 1 mg/mL, the antiproliferation of T24 by C. majus was 96 % and of MDA-MD-231 cells by A. vulgaris was 75 % after 72 h. After principal component analysis, T. chamaedrys and C. majus were grouped together. Quercetin glucoside and antioxidant capacity (DPPH) contributed the most to differentiate these infusions from the other two. Novelty and scientific contribution. This study represents a comparative analysis of the biopotential of four medicinal plants. A new RP-HPLC method was developed to separate the flavonoids in the herbal infusions. This is the first report on the presence of kaempferol-3-O-rutinoside in C. officinalis and isorhamnetin-3-O-rutinoside in A. vulgaris aqueous infusion. For the first time, C. majus has been shown to contribute to the oxidative stability of edible oil. Furthermore, this is the first comparative study on the antiproliferative activity of selected medicinal plants against the cell lines ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://hrcak.srce.hr/314924 |
| الاتاحة: | https://hrcak.srce.hr/314924 https://hrcak.srce.hr/file/456271 |
| Rights: | info:eu-repo/semantics/openAccess ; The contents of the Food Technology and Biotechnology can be used for personal, educational or scientific purposes, provided that the credit is given to the Journal (under Creative Commons licence CC BY 4.0). Annual subscription price for all countries (except Croatia) is 40 euro for citizens and 100 euro for organizations and institutions. Discount is offered to the members of Croatian Society of Biotechnology and Slovenian Microbiological Society. For subscription please contact the Editorial Office at the E-mail address: ftb@pbf.hr |
| رقم الانضمام: | edsbas.85BF8B9B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |