Academic Journal
Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis
| العنوان: | Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis |
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| المؤلفون: | Petit, Claire, Lee, Anne Wing Mui, Ma, Jun, Lacas, Benjamin, Ng, Waitong, Chan, Anthony T.C., Hong, Rueylong, Chen, Mingyuan, Chen, Lei, Li, Wenfei, Huang, Peiyu, Tan, Terence Wee Kiat, Ngan, Roger Kai Cheong, Zhu, Guopei, Mai, Haiqiang, Hui, Edwin P., Fountzilas, George, Zhang, Li, Carmel, Alexandra, Kwong, Dora Lai Wan, Moon, James, Bourhis, Jean Henri, Auperin, Anne, Pignon, Jean Pierre, Blanchard, Pierre, Aupérin, Anne, Benhamou, Ellen, Chakrabandhu, Somvilai, Chen, Qiuyan, Chen, Yong, Chappell, Richard J., Choi, Horace Cheuk Wai, Chua, Daniel T., Chua, Melvien Lee Kiang, Higgins, Julian P.T., Hong, Ming Huang, Hui, Edwin Pun, Hsiao, Chinfu, Kam, Miachael Koon Ming, Koliou, Georgia Angeliki, Lai, Shuchuan, Lam, Ka On, Leblanc, Michael L., Lee, Anne Wm, Lee, Ho Fun Victor, Lim, Yoke, Ma, Brigette Buig Yue, Mo, Frankie Kwok Fai, Ngan, Roger, Ollivier, Camille, O'Sullivan, Brian, Poh, Sharon X., Rücker, Gerta, Sham, Jonathan, Soong, Yoke Lim, Sun, Ying, Tang, Linquan, Tung, Yuk Stewart, Wee, Joseph Tien Seng, Wu, Xuang, Xu, Tingting, Zhang, Yuan |
| المساهمون: | Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique Gustave Roussy, Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Ligue Contre le Cancer, Institut National Du Cancer, INCa, (PHRC K15-189) |
| المصدر: | ISSN: 1470-2045. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; Background: The meta-analysis of chemotherapy for nasopharynx carcinoma (MAC-NPC) collaborative group previously showed that the addition of adjuvant chemotherapy to concomitant chemoradiotherapy had the highest survival benefit of the studied treatment regimens in nasopharyngeal carcinoma. Due to the publication of new trials on induction chemotherapy, we updated the network meta-analysis. Methods: For this individual patient data network meta-analysis, trials of radiotherapy with or without chemotherapy in patients with non-metastatic nasopharyngeal carcinoma that completed accrual before Dec 31, 2016, were identified and updated individual patient data were obtained. Both general databases (eg, PubMed and Web of Science) and Chinese medical literature databases were searched. Overall survival was the primary endpoint. A frequentist network meta-analysis approach with a two-step random effect stratified by trial based on hazard ratio Peto estimator was used. Global Cochran Q statistic was used to assess homogeneity and consistency, and p score to rank treatments, with higher scores indicating higher benefit therapies. Treatments were grouped into the following categories: radiotherapy alone, induction chemotherapy followed by radiotherapy, induction chemotherapy without taxanes followed by chemoradiotherapy, induction chemotherapy with taxanes followed by chemoradiotherapy, chemoradiotherapy, chemoradiotherapy followed by adjuvant chemotherapy, and radiotherapy followed by adjuvant chemotherapy. This study is registered with PROSPERO, CRD42016042524. Findings: The network comprised 28 trials and included 8214 patients (6133 [74·7%] were men, 2073 [25·2%] were women, and eight [0·1%] had missing data) enrolled between Jan 1, 1988, and Dec 31, 2016. Median follow-up was 7·6 years (IQR 6·2–13·3). There was no evidence of heterogeneity (p=0·18), and inconsistency was borderline (p=0·10). The three treatments with the highest benefit for overall survival were induction chemotherapy with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37269842; hal-04191504; https://hal.science/hal-04191504; https://hal.science/hal-04191504/document; https://hal.science/hal-04191504/file/2023_Petit_Lacas_Carmel_Auperin_Pignon_Blanchard_LancetOncol.pdf; PUBMED: 37269842 |
| DOI: | 10.1016/S1470-2045(23)00163-8 |
| الاتاحة: | https://hal.science/hal-04191504 https://hal.science/hal-04191504/document https://hal.science/hal-04191504/file/2023_Petit_Lacas_Carmel_Auperin_Pignon_Blanchard_LancetOncol.pdf https://doi.org/10.1016/S1470-2045(23)00163-8 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.859EFA07 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S1470-2045(23)00163-8 |
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