Academic Journal
International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways
| العنوان: | International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways |
|---|---|
| المؤلفون: | Rayjean J Hung, David C Christiani, Angela Risch, Odilia Popanda, Aage Haugen, Shan Zienolddiny, Simone Benhamou, Christine Bouchardy, Qing Lan, Margaret R Spitz, H.-Erich Wichmann, Loic Lemarchand, Paolo Vineis, Giuseppe Matullo, Chikako Kiyohara, Zuo-Feng Zhang, Benhnaz Pezeshki, Curtis Harris, Leah Mechanic, Adeline Seow, Daniel P K Ng, Neonila Szeszenia-Dabrowska, David Zaridze, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Lenka Foretova, Vladimir Janout, Vladimir Bencko, Neil Caporaso, Chu Chen, Eric J Duell, Gary Goodman, John K Field, Richard S Houlston, Yun-Chul Hong, Maria Teresa Landi, Philip Lazarus, Joshua Muscat, John Mclaughlin, Ann G Schwartz, Hongbing Shen, Isabelle Stucker, Kazuo Tajima, Keitaro Matsuo, Michael Thun, Ping Yang, John Wiencke, Angeline S Andrew, Stephanie Monnier, Paolo Boffetta, Paul Brennan |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://cebp.aacrjournals.org/content/cebp/17/11/3081.full.pdf. |
| سنة النشر: | 2008 |
| المجموعة: | CiteSeerX |
| الوصف: | Background: The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies. Methods: Data from 14 studies were pooled for 18 sequence variants in 12 DNA repair genes, including APEX1, OGG1, XRCC1, XRCC2, XRCC3, ERCC1, XPD, XPF, XPG, XPA, MGMT, and TP53. The total number of subjects included in the analysis for each variant ranged from 2,073 to 13,955 subjects. Results: Four of the variants were found to be weakly associated with lung cancer risk with borderline significance: these were XRCC3 T241M [heterozygote odds ratio (OR), 0.89; 95% confidence interval (95% CI), 0.79-0.99 and homozygote OR, 0.84; 95% CI, 0.71-1.00] |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1035.4338; http://cebp.aacrjournals.org/content/cebp/17/11/3081.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1035.4338 http://cebp.aacrjournals.org/content/cebp/17/11/3081.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.859DFB1E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |