Academic Journal
Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome
| العنوان: | Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome |
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| المؤلفون: | Rice, Gillian, Meyzer, Candice, Bouazza, Naïm, Hully, Marie, Boddaert, Nathalie, Semeraro, Michaela, Zeef, Leo, A.H, Rozenberg, Flore, Bondet, Vincent, Duffy, Darragh, Llibre, Alba, Baek, Jinmi, Sambe, Mame, Henry, Elodie, Jolaine, Valerie, Barnerias, Christine, Barth, Magalie, Belot, Alexandre, Cances, Claude, Debray, François-Guillaume, Doummar, Diane, Fremond, Marie-Louise, Kitabayashi, Naoki, Lepelley, Alice, Levrat, Virginie, Melki, Isabelle, Meyer, Pierre, Nougues, Marie-Christine, Renaldo, Florence, Rodéro, Mathieu, Rodriguez, Diana, Roubertie, Agathe, Seabra, Luis, Uggenti, Carolina, Abdoul, Hendy, Tréluyer, Jean-Marc, Desguerre, Isabelle, Blanche, Stéphane, Crow, Yanick |
| المساهمون: | University of Manchester Manchester, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Necker - Enfants Malades AP-HP, Université Paris Descartes - Paris 5 (UPD5), Institut Pasteur Paris (IP), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université de Lyon, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Liège, CHU Trousseau APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Annecy-Genevois Saint-Julien-en-Genevois, AP-HP Hôpital universitaire Robert-Debré Paris, Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hôpital Robert Debré, Sorbonne Université (SU), University of Edinburgh (Edin.), Supported by grants from the European Leukodystrophy Association (ELA 2012-008l1), the European Research Council (GA 309449 and 786142-E-T1IFNs), ERA-NET Neuron (MR/M501803/1), and the French National Research Agency (ANR-10-IAHU-01 and CE17001002). Medications were provided by GlaxoSmithKline and ViiV Healthcare., ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010), European Project: 309449,EC:FP7:ERC,ERC-2012-StG_20111109,T1-IFN(2013) |
| المصدر: | ISSN: 0028-4793. |
| بيانات النشر: | CCSD Massachusetts Medical Society |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | MESH: Autoimmune Diseases of the Nervous System, MESH: Cerebrovascular Circulation, MESH: Interferons, MESH: Lamivudine, MESH: Nervous System Malformations, MESH: Pilot Projects, MESH: Reverse Transcriptase Inhibitors, MESH: Zidovudine, MESH: Dideoxynucleosides, MESH: Drug Combinations, MESH: France, MESH: Gene Expression, MESH: Humans, [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; To the Editor:The Aicardi–Goutières syndrome is a genetic encephalopathy that is associated with childhood illness and death. The syndrome is hypothesized to be due to misidentification of self-derived nucleic acids as nonself and the subsequent induction of a type I interferon–mediated response that simulates an antiviral reaction.1 Endogenous retroelements, mobile genetic elements that can be transcribed to RNA and then to DNA by reverse transcription, constitute 40% of the human genome and represent a potential source of immunostimulatory nucleic acid in patients with this syndrome.2 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30566312; info:eu-repo/grantAgreement/EC/FP7/309449/EU/Definition and characterization of type I interferonopathies/T1-IFN; PUBMED: 30566312 |
| DOI: | 10.1056/NEJMc1810983 |
| الاتاحة: | https://pasteur.hal.science/pasteur-01974160 https://pasteur.hal.science/pasteur-01974160v1/document https://pasteur.hal.science/pasteur-01974160v1/file/nejmc1810983.pdf https://doi.org/10.1056/NEJMc1810983 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8584D327 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1056/NEJMc1810983 |
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