Academic Journal
Effect of 4 years of seasonal malaria chemoprevention on the acquisition of antibodies to Plasmodium falciparum antigens in Ouelessebougou, Mali
| العنوان: | Effect of 4 years of seasonal malaria chemoprevention on the acquisition of antibodies to Plasmodium falciparum antigens in Ouelessebougou, Mali |
|---|---|
| المؤلفون: | Almahamoudou Mahamar, Djibrilla Issiaka, Ahamadou Youssouf, Sidi M. Niambele, Harouna M. Soumare, Oumar Attaher, Amadou Barry, David L. Narum, Patrick E. Duffy, Brian Greenwood, Michal Fried, Alassane Dicko |
| المصدر: | Malaria Journal, Vol 20, Iss 1, Pp 1-7 (2021) |
| بيانات النشر: | BMC |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Antibody to MSP-142, AMA1, CSP, Seasonal malaria chemoprevention, Seropositivity, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Background More than 200 million people live in areas of highly seasonal malaria transmission where Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) was recommended in 2012 by WHO. This strategy is now implemented widely and protected more than 19 million children in 2018. It was previously reported that exposure to SMC reduced antibody levels to AMA1, MSP-142 and CSP, but the duration of exposure to SMC up to three 3 years, had no effect on antibody levels to MSP-142 and CSP. Methods In 2017, a cross-sectional survey was carried out 1 month after the last dose of SMC had been given to children aged 4–5 years randomly selected from areas where SMC had been given for 2 or 4 years during the malaria transmission season. A total of 461 children were enrolled, 242 children in areas where SMC had been implemented for 4 years and 219 children in areas where SMC had been implemented for 2 years. Antibody extracted from dry blood spots was used to measure IgG levels to the malaria antigens CSP, MSP-142 and AMA1 by ELISA. Results The prevalence of antibodies to MSP-142 was similar in children who had received SMC for 4 years compared to those who had received SMC for only 2 years (85.1 vs 86.0%, ajusted odd ratio (aOR) = 1.06, 95% confidence intervals (CI 0.62–1.80), p = 0.80). The prevalence of antibodies to AMA-1 and to CSP was not lower in children who received SMC for 4 years compared to those who had received SMC for only 2 years (95.3 vs 88.8%, aOR = 3.16, 95% CI 1.44–6.95, p = 0.004 for AMA-1; and 91.2 vs 81.9%, aOR = 3.14, 95% CI 1.70–5.76, p < 0.001 for CSP). Median antibody levels for anti-MSP-142 IgG were not significatively inferior in children who had received SMC for four rather than 2 years (0.88 (IQR: 0.64–1.15) and 0.95 ((0.68–1.15), respectively), anti-CSP (1.30 (1.00–1.56) and 1.17 (0.87–1.47)), and anti-AMA-1 (1.45 (1.24–1.68) and 1.41 (1.17–1.64)). Conclusion In an area of high seasonal malaria transmission, children who had received SMC for ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1475-2875 |
| Relation: | https://doi.org/10.1186/s12936-020-03542-9; https://doaj.org/toc/1475-2875; https://doaj.org/article/f2c265051b3747f19c3ece9ddc185ed0 |
| DOI: | 10.1186/s12936-020-03542-9 |
| الاتاحة: | https://doi.org/10.1186/s12936-020-03542-9 https://doaj.org/article/f2c265051b3747f19c3ece9ddc185ed0 |
| رقم الانضمام: | edsbas.85059041 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14752875 |
|---|---|
| DOI: | 10.1186/s12936-020-03542-9 |