Academic Journal
3D Bioelectronics with a Remodellable Matrix for Long‐Term Tissue Integration and Recording
| العنوان: | 3D Bioelectronics with a Remodellable Matrix for Long‐Term Tissue Integration and Recording |
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| المؤلفون: | Boys, Alexander J., Carnicer‐Lombarte, Alejandro, Güemes‐Gonzalez, Amparo, van Niekerk, Douglas C., Hilton, Sam, Barone, Damiano G., Proctor, Christopher M., Owens, Róisín M., Malliaras, George G. |
| المساهمون: | Air Force Office of Scientific Research, Human Frontier Science Program, National Institute for Health Research, Biotechnology and Biological Sciences Research Council |
| المصدر: | Advanced Materials ; volume 35, issue 8 ; ISSN 0935-9648 1521-4095 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long‐term interfaces between electronics and the body remains a challenge. Implantation of a bioelectronic device typically initiates a foreign body response, which can limit long‐term recording and stimulation efficacy. Techniques from regenerative medicine have shown a high propensity for promoting integration of implants with surrounding tissue, but these implants lack the capabilities for the sophisticated recording and actuation afforded by electronics. Combining these two fields can achieve the best of both worlds. Here, the construction of a hybrid implant system for creating long‐term interfaces with tissue is shown. Implants are created by combining a microelectrode array with a bioresorbable and remodellable gel. These implants are shown to produce a minimal foreign body response when placed into musculature, allowing one to record long‐term electromyographic signals with high spatial resolution. This device platform drives the possibility for a new generation of implantable electronics for long‐term interfacing. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/adma.202207847 |
| الاتاحة: | http://dx.doi.org/10.1002/adma.202207847 https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202207847 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/adma.202207847 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.84FD5056 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/adma.202207847 |
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