Academic Journal
Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis
| العنوان: | Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis |
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| المؤلفون: | Nishiwaki, Ryo, Imoto, Ichiro, Oka, Satoko, Yasuma, Taro, Fujimoto, Hajime, D’Alessandro-Gabazza, Corina N., Toda, Masaaki, Kobayashi, Tetsu, Osamu, Hataji, Fujibe, Kodai, Nishikawa, Kenichiro, Hamaguchi, Tetsuya, Sugimasa, Natsuko, Noji, Midori, Ito, Yoshiyuki, Takeuchi, Kenji, Cann, Isaac, Inoue, Yasuhiro, Kato, Toshio, Gabazza, Esteban C. |
| المساهمون: | Takeda Foundation, Japan Science and Technology Agency |
| المصدر: | Gut Pathogens ; volume 15, issue 1 ; ISSN 1757-4749 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Background Acute cholangitis is a severe, life-threatening infection of the biliary system that requires early diagnosis and treatment. The Tokyo Guidelines recommend a combination of clinical, laboratory, and imaging findings for diagnosis and severity assessment, but there are still challenges in identifying severe cases that need immediate intervention. The microbiota and its derived products have been implicated in the pathogenesis of acute cholangitis. Corisin is a microbiome-derived peptide that induces cell apoptosis, acute tissue injury, and inflammation. This study aimed to evaluate the potential of plasma and bile corisin as a biomarker of acute cholangitis. Methods Forty patients with acute cholangitis associated with choledocholithiasis or malignant disease were enrolled. Nine patients without acute cholangitis were used as controls. Corisin was measured by enzyme immunoassays in plasma and bile samples. Patients were classified into severe and non-severe groups. The associations of plasma and bile corisin with the clinical grade of acute cholangitis and other parameters were analyzed by univariate and multivariate regression analysis. Results Plasma and bile corisin levels were significantly higher in patients with acute cholangitis than in controls. Patients with severe acute cholangitis had significantly higher plasma and bile corisin levels than those with non-severe form of the disease. Bile corisin level was significantly correlated with markers of inflammation, coagulation, fibrinolysis, and renal function. Univariate analysis revealed a significant association of bile corisin but a weak association of plasma corisin with the clinical grade of acute cholangitis. In contrast, multivariate analysis showed a significant relationship between plasma corisin level and the disease clinical grade. The receiver operating characteristic curve analysis showed low sensitivity but high specificity for plasma and bile corisin to detect the severity of acute cholangitis. The plasma and bile corisin ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s13099-023-00587-4 |
| DOI: | 10.1186/s13099-023-00587-4.pdf |
| DOI: | 10.1186/s13099-023-00587-4/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s13099-023-00587-4 https://link.springer.com/content/pdf/10.1186/s13099-023-00587-4.pdf https://link.springer.com/article/10.1186/s13099-023-00587-4/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.84C6A72A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13099-023-00587-4 |
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