Academic Journal
Prospective evaluation of radiotherapy-induced immunologic and genetic effects in colorectal cancer oligo-metastatic patients with lung-limited disease: The prelude-1 study
| العنوان: | Prospective evaluation of radiotherapy-induced immunologic and genetic effects in colorectal cancer oligo-metastatic patients with lung-limited disease: The prelude-1 study |
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| المؤلفون: | Ottaiano A., Petito A., Santorsola M., Gigantino V., Capuozzo M., Fontanella D., Di Franco R., Borzillo V., Buonopane S., Ravo V., Scipilliti E., Totaro G., Serra M., Ametrano G., Penta R., Tatangelo F., Scognamiglio G., Di Mauro A., Di Bonito M., Napolitano M., Scala S., Rea G., Santagata S., Lombardi A., Grimaldi A., Caputo C., Crispo A., Celentano E., De Feo G., Circelli L., Savarese G., Ruggiero R., Perri F., Granata V., Botti G., Caraglia M., Nasti G., Muto P. |
| المساهمون: | Ottaiano, A., Petito, A., Santorsola, M., Gigantino, V., Capuozzo, M., Fontanella, D., Di Franco, R., Borzillo, V., Buonopane, S., Ravo, V., Scipilliti, E., Totaro, G., Serra, M., Ametrano, G., Penta, R., Tatangelo, F., Scognamiglio, G., Di Mauro, A., Di Bonito, M., Napolitano, M., Scala, S., Rea, G., Santagata, S., Lombardi, A., Grimaldi, A., Caputo, C., Crispo, A., Celentano, E., De Feo, G., Circelli, L., Savarese, G., Ruggiero, R., Perri, F., Granata, V., Botti, G., Caraglia, M., Nasti, G., Muto, P. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
| مصطلحات موضوعية: | KRAS, abscopal effect, colorectal cancer, lung metastase, stereotactic radiation therapy |
| الوصف: | Simple Summary The management of advanced colorectal cancer (CRC) has been greatly improved with integrated strategies including stereotactic radiation therapy (SRT). It is a safe and effective option, particularly in oligo-metastatic (om) CRC patients. Interestingly, it has been demonstrated that SRT can induce regression of tumors in non-irradiated regions ("abscopal effect") through stimulation of anti-tumor immune effects ("radiation-induced immunity"). We have recently shown that lung-limited omCRC is characterized by regression of tumor clones bearing specific key driver gene mutations. The aim of the PRELUDE-1 study is to assess the genetic and immunologic evolutions on tumor cancer/host cells induced by SRT in lung-limited omCRC through liquid biopsies and Next Generation Sequencing of tumor exome, HLA repertoire assessment, peripheral immune cells, and cytokine dynamics characterizations. An important secondary objective is the first prospective evaluation of the abscopal effect. The PRELUDE-1 results will help to identify subsets of patients more prone to show the abscopal effect. The PRELUDE-1 trial was registered into the clinicaltrials.gov registry on 22 April 2021, with identifier NCT04854213. Background: in recent years, the management of advanced colorectal cancer (CRC) has been greatly improved with integrated strategies including stereotactic radiation therapy (SRT). The administration of SRT has been demonstrated, particularly in oligo-metastatic (om) CRC, to be a safe and effective option. Interestingly, it has been demonstrated that SRT can induce regression of tumors in non-irradiated regions ("abscopal effect") through stimulation of anti-tumor immune effects ("radiation-induced immunity"). We have recently shown that lung-limited omCRC is characterized by regression of tumor clones bearing specific key driver gene mutations. Aims: to assess the genetic evolution on tumor cancer cells induced by SRT in lung-limited omCRC. Secondary objectives included descriptions of the abscopal effect, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34439390; info:eu-repo/semantics/altIdentifier/wos/WOS:000688926900001; volume:13; issue:16; journal:CANCERS; https://hdl.handle.net/11591/544515 |
| DOI: | 10.3390/cancers13164236 |
| الاتاحة: | https://hdl.handle.net/11591/544515 https://doi.org/10.3390/cancers13164236 |
| رقم الانضمام: | edsbas.84AD42F5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers13164236 |
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