التفاصيل البيبلوغرافية
| العنوان: |
Metformin concentration time-courses in major compartments of metformin action. |
| المؤلفون: |
Darta Maija Zake (10535788), Janis Kurlovics (10535791), Linda Zaharenko (5797694), Vitalijs Komasilovs (10535794), Janis Klovins (76934), Egils Stalidzans (10535797) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Marine Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dose, blood flow, intestine cell culture experiments, human, body fluids compartments, type 2 diabetes treatment, decision support tool, metformin concentration time-course, concentration time series, metformin pharmacokinetics model, tissue-specific pharmacokinetics pa., blood cells, precision therapy development, PBPK model, metformin PBPK model |
| الوصف: |
Plasma (A), liver (B), kidney (C), intestine (D), muscle (E), brain (F), heart (G), adipose (H), stomach (I), lungs (J), the remainder (K), red blood cells (L)—following a single PO dose of 500mg, 1000mg and 1500mg metformin hydrochloride in humans. The red lines represent the concentration-time profiles of the model simulations of the 500mg dose, the green lines represent model simulations for the 1000mg dose and the blue lines represent model simulations for the 1500mg dose. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Metformin_concentration_time-courses_in_major_compartments_of_metformin_action_/14383354 |
| DOI: |
10.1371/journal.pone.0249594.g005 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0249594.g005 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.8452BED1 |
| قاعدة البيانات: |
BASE |