Academic Journal
Marathon running and cell-cycle arrest biomarkers of acute kidney injury
| العنوان: | Marathon running and cell-cycle arrest biomarkers of acute kidney injury |
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| المؤلفون: | Leckie, T., Fitzpatrick, D., Richardson, A. J., Hunter, A., Bains, S., Grimaldi, R., Galloway, R., Forni, L. G., Hodgson, L. E. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | RD&E Research Repository (Royal Devon and Exeter NHS Foundation Trust) |
| مصطلحات موضوعية: | Acute kidney injury, Biomarker, Endurance, Igfbp7, Running, TIMP-2 |
| الوصف: | OBJECTIVES: Endurance exercise is known to cause a rise in serum creatinine. It is not known to what extent this rise reflects renal stress and a potential acute kidney injury (AKI). Increases in Insulin Like Growth Factor Binding Protein 7 (IGFBP7) and Tissue Inhibitor of Metalloprotinases-2 (TIMP-2), urinary biomarkers of cell cycle arrest and renal stress, are associated with the development of AKI in clinical populations. DESIGN: Repeated measures study. METHODS: Runners were recruited at the 2019 Brighton Marathon (UK) and provided urine and blood samples at baseline, immediately post-race and 24 h post-race. Serum creatinine, urinary creatinine and urinary IGFBP7 and TIMP-2 were analysed from the samples. RESULTS: Seventy nine participants (23 females, 56 males), aged 43 ± 10 yrs. (mean ± SD), finish time 243 ± 40mins were included for analysis. Serum creatinine increased over the race by 40 ± 26% (p < 0.001), TIMP-2 increased by 555 ± 697% (p < 0.001) and IGFBP7 increased by 1094 ± 1491% (p < 0.001) over the race. A subset of twenty-two participants supplied samples 24 h post-race, reporting values similar to baseline for all variables. CONCLUSIONS: This study is the first to report large rises in IGFBP7 and TIMP-2 following marathon running. This suggests that rises in creatinine are not fully explained by changes in production and clearance and marathon running induces a state of kidney stress and potential injury. ; 0 ; Supports Open Access |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://linkinghub.elsevier.com/retrieve/pii/S1440-2440(22)00446-7; J Sci Med Sport. 2022 Oct 24:S1440-2440(22)00446-7. doi:10.1016/j.jsams.2022.10.012.; Journal of science and medicine in sport; https://hdl.handle.net/11287/622747 |
| DOI: | 10.1016/j.jsams.2022.10.012 |
| الاتاحة: | https://hdl.handle.net/11287/622747 https://doi.org/10.1016/j.jsams.2022.10.012 |
| Rights: | © 2022 Elsevier Ltd. All rights reserved. ; http://creativecommons.org/publicdomain/zero/1.0/ |
| رقم الانضمام: | edsbas.841F634B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jsams.2022.10.012 |
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