Academic Journal
Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
| العنوان: | Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations |
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| المؤلفون: | Yang, C., Hallmark, B., Chai, J.C., O’Connor, T.D., Reynolds, L.M., Wood, A.C., Seeds, M., Chen, Y.-D.I., Steffen, L.M., Tsai, M.Y., Kaplan, R.C., Daviglus, M.L., Mandarino, L.J., Fretts, A.M., Lemaitre, R.N., Coletta, D.K., Blomquist, S.A., Johnstone, L.M., Tontsch, C., Qi, Q., Ruczinski, I., Rich, S.S., Mathias, R.A., Chilton, F.H., Manichaikul, A. |
| المساهمون: | Center for Biomedical Informatics and Biostatistics, University of Arizona, Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Department of Physiology, University of Arizona College of Medicine, Department of Nutritional Sciences, University of Arizona College of Agriculture and Life Sciences, University of Arizona Genetics Core, University of Arizona |
| المصدر: | Communications Biology |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2021 |
| المجموعة: | The University of Arizona: UA Campus Repository |
| الوصف: | Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk. © 2021, The Author(s). ; Open access journal ; This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2399-3642 |
| Relation: | Yang, C., Hallmark, B., Chai, J. C., O’Connor, T. D., Reynolds, L. M., Wood, A. C., Seeds, M., Chen, Y.-D. I., Steffen, L. M., Tsai, M. Y., Kaplan, R. C., Daviglus, M. L., Mandarino, L. J., Fretts, A. M., Lemaitre, R. N., Coletta, D. K., Blomquist, S. A., Johnstone, L. M., Tontsch, C., … Manichaikul, A. (2021). Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations. Communications Biology, 4(1).; http://hdl.handle.net/10150/661413; Communications Biology |
| DOI: | 10.1038/s42003-021-02431-4 |
| الاتاحة: | http://hdl.handle.net/10150/661413 https://doi.org/10.1038/s42003-021-02431-4 |
| Rights: | Copyright © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License. ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.83FD5BFC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23993642 |
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| DOI: | 10.1038/s42003-021-02431-4 |