Academic Journal
Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?
| العنوان: | Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions? |
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| المؤلفون: | Bashir, M R, Husarik, D B, Ziemlewicz, T J, Gupta, R T, Boll, D T, Merkle, E M |
| المصدر: | Bashir, M R; Husarik, D B; Ziemlewicz, T J; Gupta, R T; Boll, D T; Merkle, E M (2012). Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions? Journal of Magnetic Resonance Imaging, 35(3):611-616. |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 2012 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Clinic for Diagnostic and Interventional Radiology, 610 Medicine & health |
| الوصف: | PURPOSE: To compare conspicuity and detection rate of hypointense lesions on T1-weighted (T1w) gradient echo (GRE) sequences with low and high flip angles (FA) in hepatocyte phase magnetic resonance imaging (MRI) using gadoxetate disodium. MATERIALS AND METHODS: This Health Insurance Portability and Accountability Act (HIPAA)-compliant study was Institutional Review Board (IRB)-approved. The study population consisted of patients with hypointense liver lesions undergoing MRI with gadoxetate disodium, with hepatocyte-phase fat suppressed 3D T1w GRE sequences at both low (10-12°) and high (30-35°) FA. Contrast-to-noise ratios (CNRs) were calculated for liver parenchyma vs. large lesions and common bile duct (CBD) vs. liver. Three radiologists each assigned a conspicuity score (CS) for each lesion detected at low or high FA. Paired Student's t-tests compared the lesion detection (LD) rate using only the hepatocyte phase data set compared with the entire MRI examination, and CS for low and high FA. RESULTS: In all, 57 large and 70 small lesions were identified in 18 patients. Average LD and CS were significantly greater at high FA versus low FA overall (LD 89.0% vs. 79.5%; CS 2.8 vs. 2.2; P < 0.05) and for small lesions (81.4% vs. 65.7%; 2.5 vs. 1.8; P < 0.05). Average liver-to-lesion CNR for large lesions and CBD-to-liver CNR was significantly greater at high FA (P < 0.05). CONCLUSION: Increasing the FA in hepatocyte phase MRI with gadoxetate disodium improves hypointense lesion detection and conspicuity, particularly for small lesions. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1053-1807 |
| Relation: | https://www.zora.uzh.ch/52951; info:pmid/22034383; urn:issn:1053-1807 |
| DOI: | 10.1002/jmri.22850 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/52951/ https://www.zora.uzh.ch/52951 https://doi.org/10.1002/jmri.22850 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.83CB961F |
| قاعدة البيانات: | BASE |
| تدمد: | 10531807 |
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| DOI: | 10.1002/jmri.22850 |