التفاصيل البيبلوغرافية
| العنوان: |
Long-Term Intersession Variability for Single-Breath Diffusing Capacity |
| المؤلفون: |
Hegewald, Matthew J., Jensen, Robert L., Teeter, John G., Wise, Robert A., Riese, Richard J., England, Richard D., Ahrens, Richard C., Crapo, Robert O., MacIntyre, Neil R. |
| المصدر: |
Respiration ; volume 84, issue 5, page 377-384 ; ISSN 0025-7931 1423-0356 |
| بيانات النشر: |
S. Karger AG |
| سنة النشر: |
2011 |
| الوصف: |
Background: Characterizing long-term diffusing capacity (Dl CO ) variability is important in assessing quality control for Dl CO equipment and patient management. Long-term Dl CO variability has not been reported. Objectives: It was the aim of this study to characterize long-term variability of Dl CO in a cohort of biocontrols and to compare different methods of selecting a target value. Methods: Longitudinal Dl CO monitoring of biocontrols was performed as part of the inhaled insulin development program; 288 biocontrols were tested twice monthly for up to 5 years using a standardized technique. Variability, expressed either as percent change or Dl CO units, was assessed using three different target values. Results: The 90th percentile for mean intersession change in Dl CO was between 10.9 and 15.8% (2.6–4.1 units) depending on the target value. Variability was lowest when the mean of all Dl CO tests was used as the target value and highest when the baseline Dl CO was used. The average of the first six Dl CO tests provided an accurate estimate of the mean Dl CO value. Using this target, the 90th percentile for mean intersession change was 12.3% and 3.0 units. Variability was stable over time and there were no meaningful associations between variability and demographic factors. Conclusions: Dl CO biocontrol deviations >12% or >3.0 units, from the average of the first six tests, indicate that the instrument is not within quality control limits and should be carefully evaluated before further patient testing. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1159/000334699 |
| الاتاحة: |
http://dx.doi.org/10.1159/000334699
https://www.karger.com/Article/Pdf/334699 |
| Rights: |
https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| رقم الانضمام: |
edsbas.83CA991B |
| قاعدة البيانات: |
BASE |