Academic Journal
Clinicopathological features and treatment outcome of oesophageal gastrointestinal stromal tumour (GIST): A large, retrospective multicenter European study
| العنوان: | Clinicopathological features and treatment outcome of oesophageal gastrointestinal stromal tumour (GIST): A large, retrospective multicenter European study |
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| المؤلفون: | Mohammadi, M., IJzerman, Nikki S., Hohenberger, P., Rutkowski, P., Jones, R.L., Martin-Broto, J., Gronchi, A., Schöffski, P, Vassos, N., Farag, S., Baia, M., Oosten, A.W., Steeghs, N., Desar, I.M.E., Reyners, A.K., Sandick, J.W. van, Bastiaannet, E., Gelderblom, H., Schrage, Y. |
| المصدر: | European Journal of Surgical Oncology, 47, 8, pp. 2173-2181 |
| سنة النشر: | 2021 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences |
| الوصف: | Contains fulltext : 235268.pdf (Publisher’s version ) (Open Access) ; BACKGROUND: Oesophageal gastrointestinal stromal tumours (GISTs) account for ≤1% of all GISTs. Consequently, evidence to guide clinical decision-making is limited. METHODS: Clinicopathological features and outcomes in patients with primary oesophageal GIST from seven European countries were collected retrospectively. RESULTS: Eighty-three patients were identified, and median follow up was 55.0 months. At diagnosis, 59.0% had localized disease, 25.3% locally advanced and 13.3% synchronous metastasis. A biopsy (Fine Needle aspiration n = 29, histological biopsy n = 31) was performed in 60 (72.3%) patients. The mitotic count was low (<5 mitoses/50 High Power Fields (HPF)) in 24 patients and high (≥5 mitoses/50 HPF) in 27 patients. Fifty-one (61.4%) patients underwent surgical or endoscopic resection. The most common reasons to not perform an immediate resection (n = 31) were; unresectable or metastasized GIST, performance status/comorbidity, patient refusal or ongoing neo-adjuvant therapy. The type of resections were enucleation (n = 11), segmental resection (n = 6) and oesophagectomy with gastric conduit reconstruction (n = 33), with median tumour size of 3.3 cm, 4.5 cm and 7.7 cm, respectively. In patients treated with enucleation 18.2% developed recurrent disease. The recurrence rate in patients treated with segmental resection was 16.7% and in patients undergoing oesophagectomy with gastric conduit reconstruction 36.4%. Larger tumours (≥4.0 cm) and high (>5/5hpf) mitotic count were associated with worse disease free survival. CONCLUSION: Based on the current study, enucleation can be recommended for oesophageal GIST smaller than 4 cm, while oesophagectomy should be preserved for larger tumours. Patients with larger tumours (>4 cm) and/or high mitotic count should be treated with adjuvant therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://repository.ubn.ru.nl//bitstream/handle/2066/235268/235268.pdf; https://repository.ubn.ru.nl/handle/2066/235268; https://doi.org/10.1016/j.ejso.2021.03.234 |
| DOI: | 10.1016/j.ejso.2021.03.234 |
| الاتاحة: | https://repository.ubn.ru.nl//bitstream/handle/2066/235268/235268.pdf https://repository.ubn.ru.nl/handle/2066/235268 https://doi.org/10.1016/j.ejso.2021.03.234 |
| رقم الانضمام: | edsbas.83B872FA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejso.2021.03.234 |
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