التفاصيل البيبلوغرافية
| العنوان: |
Differentiated Epithelial- and Mesenchymal-Like Phenotypes in Subcutaneous Mouse Xenografts Using Diffusion Weighted-Magnetic Resonance Imaging |
| المؤلفون: |
Ya-Wen Chen, Huay-Ben Pan, Hui-Hwa Tseng, Hsiao-Chien Chu, Yu-Ting Hung, Yi-Chen Yen, Chen-Pin Chou |
| المصدر: |
International Journal of Molecular Sciences; Volume 14; Issue 11; Pages: 21943-21959 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2013 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
diffusion-weighted magnetic resonance imaging, epithelial, mesenchymal, apparent diffusion coefficient, mouse xenografts |
| جغرافية الموضوع: |
agris |
| الوصف: |
Epithelial-mesenchymal transition (EMT) is important for tumor metastasis. Detection of EMT protein expression and observation of morphological changes are commonly used to identify EMT. Diffusion-weighted magnetic resonance imaging (DW-MRI) and measuring apparent diffusion coefficient (ADC) values are noninvasive techniques for characterizing tumor microenvironments. We investigated the difference in ADC values between epithelial- and mesenchymal-like subcutaneous mouse xenografted tumors using DW-MRI. Epithelial-like MM189 PB-Klf4 and BL322 PB-Klf4 cells were generated from tumor suppressive Kruppel-like factor 4 (Klf4)-expressing mesenchymal-like MM189 and BL322 cells. The ADC values of xenografted tumors from epithelial-like MM189 PB-Klf4 and BL322 PB-Klf4 were significantly lower than those from their mesenchymal-like counterparts (p < 0.05 and p < 0.01, respectively). Our results suggested that DW-MRI is a potential tool for observing mesenchymal- or epithelial-like characteristics of subcutaneous xenografted tumors. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Biochemistry; https://dx.doi.org/10.3390/ijms141121943 |
| DOI: |
10.3390/ijms141121943 |
| الاتاحة: |
https://doi.org/10.3390/ijms141121943 |
| Rights: |
https://creativecommons.org/licenses/by/3.0/ |
| رقم الانضمام: |
edsbas.838A9C13 |
| قاعدة البيانات: |
BASE |