Academic Journal
Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S 3 System: Results from the RECAP Study
| العنوان: | Two Years’ Experience of Intensive Home Hemodialysis with the Physidia S 3 System: Results from the RECAP Study |
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| المؤلفون: | Hafedh Fessi, Philippe Nicoud, Tomas Serrato, Olivia Gilbert, Cécile Courivaud, Salima Daoud, Marion Morena, Michel Thomas, Bernard Canaud, Jean-Paul Cristol |
| المصدر: | Journal of Clinical Medicine, Vol 12, Iss 4, p 1357 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | intensified hemodialysis, slow daily dialysis, dialysis efficiency, adequacy, dialysis quantification, Medicine |
| الوصف: | The RECAP study reports results and outcomes (clinical performances, patient acceptance, cardiac outcomes, and technical survival) achieved with the S 3 system used as an intensive home hemodialysis (HHD) platform over a three-year French multicenter study. Ninety-four dialysis patients issued from ten dialysis centers and treated more than 6 months (mean follow-up: 24 months) with S 3 were included. A two-hour treatment time was maintained in 2/3 of patients to deliver 25 L of dialysis fluid, while 1/3 required up to 3 h to achieve 30 L. The additional convection volume produced by means of the SeCoHD tool (internal filtration backfiltration) was 3 L/session, and the net ultrafiltration produced to achieve dry weight was 1.4 L/session. On a weekly basis, an average 156 L of dialysate corresponding to 94 L of urea clearance when considering 85% dialysate saturation under low flow conditions was delivered. Such urea clearance was equivalent to 9.2 [8.0–13.0] mL/min weekly urea clearance and a standardized Kt/V of 2.5 [1.1–4.5]. The predialysis concentration of selected uremic markers remained remarkably stable over time. Fluid volume status and blood pressure were adequately controlled by means of a relatively low ultrafiltration rate (7.9 mL/h/kg). Technical survival on S 3 was 72% and 58% at 1 and 2 years, respectively. The S 3 system was easily handled and kept by patients at home, as indicated by technical survival. Patient perception was improved, while treatment burden was reduced. Cardiac features (assessed in a subset of patients) tended to improve over time. Intensive hemodialysis relying on the S 3 system offers a very appealing option for home treatment with quite satisfactory results, as shown in the RECAP study throughout a two-year follow-up time, and offers the best bridging solution to kidney transplantation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2077-0383 |
| Relation: | https://www.mdpi.com/2077-0383/12/4/1357; https://doaj.org/toc/2077-0383; https://doaj.org/article/4fdd4d63711149bf8122d04c47b6e996 |
| DOI: | 10.3390/jcm12041357 |
| الاتاحة: | https://doi.org/10.3390/jcm12041357 https://doaj.org/article/4fdd4d63711149bf8122d04c47b6e996 |
| رقم الانضمام: | edsbas.83737328 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm12041357 |