Academic Journal
Teratogenic activity of HDAC inhibitors
| العنوان: | Teratogenic activity of HDAC inhibitors |
|---|---|
| المؤلفون: | E. Giavini, E. Menegola |
| المساهمون: | E. Giavini, E. Menegola |
| بيانات النشر: | Bentham Science Publishers |
| سنة النشر: | 2014 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | congenital malformation, HDAC inhibitor, mechanism, teratogenesis, Settore BIO/06 - Anatomia Comparata e Citologia, Settore BIO/14 - Farmacologia |
| الوصف: | Modification of the terminal tails of histones is considered one of the documented mechanism for epigenetic control of gene expression. Histone deacetylase inhibitors (HDACi) lead to a state of hyperacetylation of histone, a condition that can affect normal gene transcription. Furthermore, HDACi have many other protein targets involved in regulation of gene expression, cell proliferation and cell death. For these properties some HDACi are nowadays used as anticancer drugs with promising results. Several molecules with HDACi properties (valproic acid, trichostatin A, apicidin, MS-275, sodium butyrate, boric acid, salicylic acid) have been found to induce congenital malformations associated with hyperacetylation of histones in the target organs. Cell death is the major event in the target organs a few hours after embryonic exposure to HDACi. Gene deregulation, oxidative stress, DNA demethylation, and/or retinoic acid imbalance are the modes of action postulated for HDACi-induced teratogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/24502598; info:eu-repo/semantics/altIdentifier/wos/WOS:000305337600026; volume:20; issue:34; firstpage:5438; lastpage:5442; numberofpages:5; journal:CURRENT PHARMACEUTICAL DESIGN; http://hdl.handle.net/2434/233813; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925844825 |
| DOI: | 10.2174/1381612820666140205144900 |
| الاتاحة: | http://hdl.handle.net/2434/233813 https://doi.org/10.2174/1381612820666140205144900 |
| رقم الانضمام: | edsbas.836EE00A |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1381612820666140205144900 |
|---|