Academic Journal
Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease
| العنوان: | Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease |
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| المؤلفون: | Rodríguez-Fernández, Blanca, Sánchez Benavides, Gonzalo, Genius, Patricia, Minguillón, Carolina, Fauria, Karine, De Vivo, Immaculata, Navarro i Cuartiellas, Arcadi, 1969-, Molinuevo, José Luis, Gispert López, Juan Domingo, Sala Vila, Aleix, Vilor Tejedor, Natàlia, 1988-, Crous-Bou, Marta, ALFA Study |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) |
| مصطلحات موضوعية: | Alzheimer’s disease, Biological aging, Cognitive performance, Sex differences, Telomere length |
| الوصف: | Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns. ; The project leading to these results has received funding from the Alzheimer’s Association (Grant AARG-19–618265). This project has received funding from Instituto de Salud Carlos III (PI19/00119). Additional support has been received from 'la Caixa' Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004, the Alzheimer’s Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17–519007), the Health Department of the Catalan Government (Health Research and Innovation Strategic Plan (PERIS) 2016–2020 grant# SLT002/16/00201), and the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2017-SGR-892. All CRG authors acknowledge the support of the Spanish Ministry of Science, Innovation, and Universities to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Programme / Generalitat de Catalunya. JDG is supported by the Spanish Ministry of Science and Innovation (RYC-2013–13054). GSB has received funding ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Neurobiol Aging. 2024 Jun 1;141:140-50; info:eu-repo/grantAgreement/ES/2PE/PID2020–119556RA-I00; http://hdl.handle.net/10230/60762; http://dx.doi.org/10.1016/j.neurobiolaging.2024.05.015 |
| DOI: | 10.1016/j.neurobiolaging.2024.05.015 |
| الاتاحة: | http://hdl.handle.net/10230/60762 https://doi.org/10.1016/j.neurobiolaging.2024.05.015 |
| Rights: | © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.83643A26 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neurobiolaging.2024.05.015 |
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