Academic Journal
Maternal plasma vitamin D levels across pregnancy are not associated with neonatal birthweight: findings from an Australian cohort study of low-risk pregnant women
| العنوان: | Maternal plasma vitamin D levels across pregnancy are not associated with neonatal birthweight: findings from an Australian cohort study of low-risk pregnant women |
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| المؤلفون: | Paige van der Pligt, Stacey J Ellery, Deborah L de Guingand, Gavin Abbott, Paul A Della Gatta, Robin Daly |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Reproductive medicine not elsewhere classified, Nursing not elsewhere classified, Public health not elsewhere classified, Birth size, Birthweight, Macrosomia, Obesity, Pregnancy, Vitamin D |
| الوصف: | Background In utero environments can be highly influential in contributing to the development of offspring obesity. Specifically, vitamin D deficiency during pregnancy is associated with adverse maternal and child health outcomes, however its relationship with offspring obesity remains unclear. We assessed maternal vitamin D status across pregnancy, change in plasma vitamin D concentrations and associations with neonatal birthweight, macrosomia and large for gestational age. Methods Women (n = 221) aged 18–40 years with singleton (low-risk) pregnancies, attending antenatal clinics at a tertiary-level maternity hospital were recruited at 10–20 weeks gestation. Medical history, maternal weight and blood samples at three antenatal clinic visits were assessed; early (15 ± 3 weeks), mid (27 ± 2 weeks) and late (36 ± 1 weeks) gestation. Maternal 25(OH)D was analysed from stored plasma samples via liquid chromatography-tandem mass spectrometry (LC/MS/MS). Neonatal growth parameters were collected at birth. Unadjusted and adjusted linear and logistic regression assessed associations of maternal vitamin D with birthweight, macrosomia and large for gestational age. Results Mean plasma 25(OH)D increased from early (83.8 ± 22.6 nmol/L) to mid (96.5 ± 28.9 nmol/L) and late (100.8 ± 30.8 nmol/L) gestation. Overall 98% of women were taking vitamin D-containing supplements throughout their pregnancy. Prevalence of vitamin D deficiency (25(OH)D < 50 nmol/L) was 6.5%, 6.3% and 6.8% at early, mid and late pregnancy respectively. No statistically significant association was found between 25(OH)D or vitamin D deficiency at any timepoint with neonatal birthweight, macrosomia or large for gestational age. Conclusions Prevalence of vitamin D deficiency was low in this cohort of pregnant women and likely related to the high proportion of women taking vitamin D supplements during pregnancy. Maternal 25(OH)D did not impact offspring birth weight or birth size. Future studies in high-risk pregnant populations are needed to ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/10779/DRO/DU:22124672.v2 |
| الاتاحة: | http://hdl.handle.net/10779/DRO/DU:22124672.v2 https://figshare.com/articles/journal_contribution/Maternal_plasma_vitamin_D_levels_across_pregnancy_are_not_associated_with_neonatal_birthweight_findings_from_an_Australian_cohort_study_of_low-risk_pregnant_women/22124672 |
| Rights: | All Rights Reserved |
| رقم الانضمام: | edsbas.8351B993 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |