Academic Journal
Neuropsychiatric Symptoms Among Hispanics: Results of the Maracaibo Aging Study
| العنوان: | Neuropsychiatric Symptoms Among Hispanics: Results of the Maracaibo Aging Study |
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| المؤلفون: | Gil, Mario, Alliey-Rodriguez, Ney, Lopez Alvarenga, Juan Carlos, Diego, Vincent P., Gaona, Ciro, Mata, Ledys, Pirela, Rosa V, Chavez, Carlos A., de Erausquin, Gabriel A., Melgarejo, Jesus D., Maestre, Gladys E. |
| المصدر: | School of Medicine Publications and Presentations |
| بيانات النشر: | ScholarWorks @ UTRGV |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Aging, Alzheimer’s disease, cognitive impairment, dementia, hispanics, neuropsychiatric inventory, Diseases, Medicine and Health Sciences |
| الوصف: | Background: Neuropsychiatric symptoms play an important role in diagnosing and clinical follow-up of cognitive impairment and dementia. Objective: We investigated the relationship between neuropsychiatric symptoms, cognitive impairment, and dementia in Hispanics. Methods: We included 529 participants (age ≥40 years) from the Maracaibo Aging Study with standardized neuropsychiatric assessments, including the Neuropsychiatric Inventory (NPI). Based on the Clinical Dementia Rating and the Mini-Mental State Examination scores, participants’ cognitive status was categorized into normal cognition, mild/moderate, and severe cognitive impairment. Diagnosis of dementia was established in a consensus conference. Statistical analyses included multivariable logistic regression models and area under the curve (AUC). Results: The mean age of participants was 59.3 years, and 71.8% were women. The proportion of dementia was 6.8%. Disturbed sleep, anxiety, and depression were the most common neuropsychiatric symptoms in the study sample. In crude analyses, the proportions of hallucinations, aberrant motor behavior, agitation/aggression, apathy, delusions, irritability, eating disturbance, depression, and euphoria were differently distributed among cognitive status groups (p < 0.05). After accounting for confounders, aberrant motor behavior and agitation/aggression remained significantly associated with cognitive impairment and dementia (p < 0.05). The inclusion of the NPI domains significantly improved the AUC to discriminate severe cognitive impairment and dementia above of a basic model that included sex, age, education, alcohol, obesity, serum glucose, total cholesterol, hypertension, and stroke. Conclusion: Neuropsychiatric symptoms are associated with severe cognitive impairment and dementia. The addition of NPI items to the global cognitive assessment might help early detection of dementia in primary care settings. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://scholarworks.utrgv.edu/som_pub/398; https://scholarworks.utrgv.edu/context/som_pub/article/1399/viewcontent/nihms_1723409Neuropsychiatric_Symptoms_Among_Hispanics_Results_of_the.pdf |
| DOI: | 10.3233/JAD-201144 |
| الاتاحة: | https://scholarworks.utrgv.edu/som_pub/398 https://doi.org/10.3233/JAD-201144 https://scholarworks.utrgv.edu/context/som_pub/article/1399/viewcontent/nihms_1723409Neuropsychiatric_Symptoms_Among_Hispanics_Results_of_the.pdf |
| رقم الانضمام: | edsbas.82F79C45 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3233/JAD-201144 |
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