Academic Journal
Impact of anemia on platelet production and function in acute coronary syndrome: results of long-term single-center registry
| العنوان: | Impact of anemia on platelet production and function in acute coronary syndrome: results of long-term single-center registry |
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| المؤلفون: | Malinova, L, Dolotovskaya, P, Furman, N, Radzhabov, KH |
| المصدر: | European Heart Journal. Acute Cardiovascular Care ; volume 10, issue Supplement_1 ; ISSN 2048-8726 2048-8734 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| الوصف: | Funding Acknowledgements Type of funding sources: None. Anemia is the most common clinical condition known to increase both ischemic and hemorrhagic risks in patients with acute coronary syndrome (ACS). Despite it"s high frequency there are certain gaps in evidence on how to choose appropriate antiplatelet regimen in anemia, for anemia was among exclusion criteria in almost all randomized clinical trials on efficacy and safety of antiplatelet agents. Purpose of the study to evaluate prevalence of anemia and it"s impact on platelet production and function in patients admitted to ICU with ACS. Methods. To determine the prevalence and characteristics of anemia we analyzed data from the local single-center long-term registry of coronary heart disease (n total= 4776, n ACS = 765). To evaluate platelet production and function we used data obtained from those patients with ACS in whom platelet function, immature platelet fraction (IPF), thrombopoietin (TPO), stromal cell-derived factor 1 (SDF1), TPO receptors (MPL) and platelet derived microparticles (PDMP) were measured serially at admission, on the second and on the 7th day since ACS manifestation (n = 321). Results. Anemia on admission was verified in 12.5% of ACS, and there were no significant differences in antiplatelet therapy at first medical contact and on admission. Anemia in patients with ACS was accompanied with decreased platelet count, therefore TPO level at admission was higher: 336.23 (141.35; 429.85) ng/mL vs 266.04 (199.16; 341.20) pg/mL, p = 0.050. PDMP level at admission was minimal in anemic patients: 6.75 (5.31; 7.81) vs 26.45 (16.05; 39.35) ng/mL (p = 0.027). There were no significant differences in TPO levels measured on the 2nd and the 7th days, as well as SDF and MPL. IPF was also comparable in anemic patients and those with normal Hb levels. Despite similar platelet function on admission in patients with anemia there was significant increase in platelet ADP-induced aggregation and secretion with maximal level at the 7th day since ACS ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ehjacc/zuab020.053 |
| الاتاحة: | https://doi.org/10.1093/ehjacc/zuab020.053 http://academic.oup.com/ehjacc/article-pdf/10/Supplement_1/zuab020.053/37406748/zuab020.053.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.82D5C586 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjacc/zuab020.053 |
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