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Risk of bias evaluation of included studies.
| العنوان: | Risk of bias evaluation of included studies. |
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| المؤلفون: | Qianqian Dai, Yanfeng Zhang, Qian Liu, Chijin Zhang |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Medicine, Biotechnology, Developmental Biology, Science Policy, Infectious Diseases, Virology, serious adverse effects, provide stronger evidence, july 7 2023, new prognostic index, crp change value, pooled analyses showed, pasi change values, pasi change value, psoriasis remains unremarkable, pdi )/ c, analysis , systematic literature search, systematic review, severity index, crp ), subgroup analyses, sensitivity analyses, |
| الوصف: | Objectives Our aim was to analyze the results of published randomized controlled trials (RCTs) on vitamin D supplementation for psoriasis in order to explore its effectiveness and safety. Patients and methods As of July 7 2023, we conducted a systematic literature search in PubMed, Cochrane, Embase, and Web of Science Core Collection databases. The study outcomes included change values in Psoriasis Area and Severity Index (PASI) (at 3 months, 6 months, and end of follow-up)/Dermatology Life Quality Index (DLQI)/Psoriasis disability index (PDI)/C-reactive protein (CRP), and adverse events. Results 333 patients from 4 studies were evaluated. Pooled analyses showed no significant effect of DLQI/PDI/CRP change value (P > 0.05) or PASI change value (3 months, end of follow-up; P > 0.05). Sensitivity analyses and statistical tests did not support the results of the PASI change values (6 months, P = 0.05). However, the results of subgroup analyses should not be ignored(supplementation with vitamin D2 or Asia would be more effective; P = 0.03). There were no serious adverse effects, and only a few individuals experienced nausea. Conclusions The efficacy and safety of vitamin D supplementation in the treatment of psoriasis remains unremarkable. The search for a new prognostic index that combines clinical and laboratory factors is needed to compensate for the shortcomings of existing measures and provide stronger evidence of validity. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Risk_of_bias_evaluation_of_included_studies_/24568053 |
| DOI: | 10.1371/journal.pone.0294239.g002 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0294239.g002 https://figshare.com/articles/figure/Risk_of_bias_evaluation_of_included_studies_/24568053 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.82CD6CF7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0294239.g002 |
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