Academic Journal
Outcomes of Endoscopic Submucosal Dissection for High-Risk Colorectal Colitis-Associated Neoplasia in Inflammatory Bowel Disease
| العنوان: | Outcomes of Endoscopic Submucosal Dissection for High-Risk Colorectal Colitis-Associated Neoplasia in Inflammatory Bowel Disease |
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| المؤلفون: | Maselli, Roberta, de Sire, Roberto, Barbaro, Federico, Cecinato, Paolo, Andrisani, Gianluca, Rosa Rizzotto, Erik, Sferrazza, Sandro, Fiori, Giancarla, Azzolini, Francesco, Pugliese, Francesco, Facciorusso, Antonio, Spadaccini, Marco, Capogreco, Antonio, Massimi, Davide, Alfarone, Ludovico, Chiappetta, Michele Francesco, Gubbiotti, Alessandro, Menini, Maddalena, Khalaf, Kareem, Sassatelli, Romano, Di Matteo, Francesco Maria, Spada, Cristiano, Hassan, Cesare, Repici, Alessandro, Armuzzi, Alessandro |
| المساهمون: | Maselli, Roberta, de Sire, Roberto, Barbaro, Federico, Cecinato, Paolo, Andrisani, Gianluca, Rosa Rizzotto, Erik, Sferrazza, Sandro, Fiori, Giancarla, Azzolini, Francesco, Pugliese, Francesco, Facciorusso, Antonio, Spadaccini, Marco, Capogreco, Antonio, Massimi, Davide, Alfarone, Ludovico, Chiappetta, Michele Francesco, Gubbiotti, Alessandro, Menini, Maddalena, Khalaf, Kareem, Sassatelli, Romano, Di Matteo, Francesco Maria, Spada, Cristiano, Hassan, Cesare, Repici, Alessandro, Armuzzi, Alessandro |
| سنة النشر: | 2025 |
| المجموعة: | Università del Salento: CINECA IRIS |
| الوصف: | Introduction: Inflammatory bowel disease (IBD) patients have an increased risk of developing colorectal cancer. High-risk colorectal colitis-associated neoplasia (HR-CAN) can be difficult to treat using traditional endoscopic resection methods. Aim of the study is to evaluate the outcomes of endoscopic submucosal dissection (ESD) on IBD patients with HR-CANs. Methods: In this retrospective multicenter study, we consecutively included IBD patients referred to expert Italian endoscopy centers who underwent ESD or hybrid-ESD (hESD) for HR-CANs. Main outcomes were the rate of en-bloc, R0, curative resections, adverse events (AEs), the rate of local recurrence, metachronous lesions, and post-resection surgery. Kaplan-Meier method was used to analyze survival curves. Risk factors associated to main outcomes were investigated by univariable analysis. Results: Ninety-one colonic IBD patients (83.4% ulcerative colitis, disease duration of 15.3 ± 8.7 years) with 96 HR-CANs (53.1% high-grade dysplasia/adenocarcinoma, size 34.8 mm ± 16.2 mm) were included. ESD and hESD were performed in 82.3% and 17.7% of cases. En-bloc, R0, and curative resections were achieved in 95.9% (95% CI 0.958; 0.896-0.988), 85.4% (95% CI 0.854; 0.767-0.917), and 83.3% (95% CI 0.833; 0.743-0.901) of cases. AEs occurred in 12.5% (95% CI 0.125; 0.066-0.208) of cases, which were all conservatively managed. After a mean follow-up of 23.4 ± 16.1 months, local recurrence and metachronous lesions occurred each in 3.1% (95% CI 0.031; 0.006-0.088) of cases. Post-resection surgery was required in 11.5% (95%CI 0.114; 0.058-0.195) of cases. Conclusions: ESD of HR-CANs shows favorable outcomes on the medium and long-term course in IBD patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | volume:In press; journal:ENDOSCOPY; https://hdl.handle.net/11587/544566 |
| DOI: | 10.1055/a-2524-3553 |
| الاتاحة: | https://hdl.handle.net/11587/544566 https://doi.org/10.1055/a-2524-3553 |
| رقم الانضمام: | edsbas.82B1AAF0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1055/a-2524-3553 |
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