Academic Journal
Plasma neuropeptide levels in patients with schizophrenia, bipolar disorder, or major depressive disorder and healthy controls: A multiplex immunoassay study
| العنوان: | Plasma neuropeptide levels in patients with schizophrenia, bipolar disorder, or major depressive disorder and healthy controls: A multiplex immunoassay study |
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| المؤلفون: | Hidese, Shinsuke, Yoshida, Fuyuko, Ishida, Ikki, Matsuo, Junko, Hattori, Kotaro, Kunugi, Hiroshi |
| المساهمون: | Japan Society for the Promotion of Science |
| المصدر: | Neuropsychopharmacology Reports ; volume 43, issue 1, page 57-68 ; ISSN 2574-173X 2574-173X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aim We aimed to compare neuropeptide levels between patients with major psychiatric disorders and healthy controls and examine their association with symptoms and cognitive function. Methods The participants were 149 patients with schizophrenia, 115 patients with bipolar disorder (BD), 186 unremitted patients with major depressive disorder (MDD), and 350 healthy controls. Psychiatric (schizophrenic, manic, and depressive) symptoms, sleep state, and cognitive (premorbid intelligence quotient, general cognitive, and memory) functions were evaluated. A multiplex immunoassay kit was used to measure cerebrospinal fluid (CSF) and plasma α‐melanocyte‐stimulating hormone (MSH), β‐endorphin, neurotensin, oxytocin, and substance P levels. Results The verification assay revealed that CSF α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels were too low to be reliably measured, while plasma α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels could be successfully measured. Plasma α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels were not significantly different between patients with schizophrenia, BD, or MDD and healthy controls. Plasma α‐MSH, β‐endorphin, neurotensin, oxytocin, and substance P levels were not significantly correlated with psychiatric symptom scores in patients with schizophrenia, BD, or MDD and cognitive function scores in patients or healthy controls. Conclusion Our data suggest that plasma neuropeptide levels do not elucidate the involvement of neuropeptides in the pathology of schizophrenia, BD, or MDD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/npr2.12304 |
| الاتاحة: | http://dx.doi.org/10.1002/npr2.12304 https://onlinelibrary.wiley.com/doi/pdf/10.1002/npr2.12304 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/npr2.12304 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.82AD56DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/npr2.12304 |
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