Academic Journal
Oxymatrine attenuates amyloid beta 42 (Aβ 1–42 )-induced neurotoxicity in primary neuronal cells and memory impairment in rats
| العنوان: | Oxymatrine attenuates amyloid beta 42 (Aβ 1–42 )-induced neurotoxicity in primary neuronal cells and memory impairment in rats |
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| المؤلفون: | Dong, Peiliang, Ji, Xiaomeng, Han, Wei, Han, Hua |
| المصدر: | Canadian Journal of Physiology and Pharmacology ; volume 97, issue 2, page 99-106 ; ISSN 0008-4212 1205-7541 |
| بيانات النشر: | Canadian Science Publishing |
| سنة النشر: | 2019 |
| الوصف: | Amyloid beta 42 (Aβ 1–42 )-induced oxidative stress causes the death of neuronal cells and is involved in the development of Alzheimer’s disease. Oxymatrine (OMT) inhibits oxidative stress. In this study, we investigated the effect of OMT on Aβ 1–42 -induced neurotoxicity in vivo and in vitro. In the Morris water maze test, OMT significantly decreased escape latency and increased the number of platform crossings. In vitro, OMT markedly increased cell viability and superoxide dismutase activity. Moreover, OMT decreased lactate dehydrogenase leakage, malondialdehyde content, and reactive oxygen species in a dose-dependent manner. OMT upregulated the ratio of Bcl-2/Bax and downregulated the level of caspase-3. Furthermore, OMT inhibited the activation of MAP kinase (ERK 1/2, JNK) and nuclear factor κB. In summary, OMT may potentially be used in the treatment of Alzheimer’s disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1139/cjpp-2018-0299 |
| الاتاحة: | http://dx.doi.org/10.1139/cjpp-2018-0299 http://www.nrcresearchpress.com/doi/full-xml/10.1139/cjpp-2018-0299 http://www.nrcresearchpress.com/doi/pdf/10.1139/cjpp-2018-0299 |
| Rights: | http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining |
| رقم الانضمام: | edsbas.82A95BF3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1139/cjpp-2018-0299 |
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