Academic Journal
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.
| العنوان: | Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. |
|---|---|
| المؤلفون: | Pirot, Pierre, Cardozo, Alessandra K, Eizirik, Decio L. |
| المصدر: | Arquivos brasileiros de endocrinologia e metabologia, 52 (2 |
| سنة النشر: | 2008 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Animals, Apoptosis -- immunology, Autoantibodies -- immunology, Cytokines -- immunology, Cytokines -- pharmacology, Diabetes Mellitus, Type 1 -- immunology, Endoplasmic Reticulum -- immunology, Endoplasmic Reticulum -- physiology, Immune System -- immunology, Immune System -- physiopathology, Immunity, Cellular -- immunology, Insulin -- immunology, Insulin -- metabolism, Insulin-Secreting Cells -- immunology, Insulin-Secreting Cells -- pathology, Major Histocompatibility Complex -- genetics, Mice, Inbred NOD, Polymorphism, Genetic, Apoptosis, Cytokines, Endoplasmic reticulum, ER stress, Pancreatic beta-cell |
| الوصف: | Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from chronic and progressive destruction of pancreatic beta-cells by the immune system. The triggering of autoimmunity against the beta-cells is probably caused by environmental agent(s) acting in the context of a predisposing genetic background. Once activated, the immune cells invade the islets and mediate their deleterious effects on beta-cells via mechanisms such as Fas/FasL, perforin/granzyme, reactive oxygen and nitrogen species and pro-inflammatory cytokines. Binding of cytokines to their receptors on the beta-cells activates MAP-kinases and the transcription factors STAT-1 and NFkappa-B, provoking functional impairment, endoplasmic reticulum stress and ultimately apoptosis. This review discusses the potential mediators and mechanisms leading to beta-cell destruction in T1D. ; Journal Article ; Research Support, Non-U.S. Gov't ; Review ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| Relation: | uri/info:doi/10.1590/S0004-27302008000200003; uri/info:pii/S0004-27302008000200003; uri/info:pmid/18438526; uri/info:scp/43249096519; https://dipot.ulb.ac.be/dspace/bitstream/2013/51320/3/doi_26392.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51320 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51320 https://dipot.ulb.ac.be/dspace/bitstream/2013/51320/3/doi_26392.pdf |
| رقم الانضمام: | edsbas.828ECE18 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |