Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency

التفاصيل البيبلوغرافية
العنوان:	Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency
المؤلفون:	Bryan J. González, Haoquan Zhao, Jacqueline Niu, Damian J. Williams, Jaeyop Lee, Chris N. Goulbourne, Yuan Xing, Yong Wang, Jose Oberholzer, Maria H. Blumenkrantz, Xiaojuan Chen, Charles A. LeDuc, Wendy K. Chung, Henry M. Colecraft, Jesper Gromada, Yufeng Shen, Robin S. Goland, Rudolph L. Leibel, Dieter Egli
المصدر:	Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
بيانات النشر:	Nature Portfolio
سنة النشر:	2022
المجموعة:	Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية:	Biology (General), QH301-705.5
الوصف:	hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretion, demonstrating a basis to treat HNF1A-MODY patients with sulfonylureas.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
تدمد:	2399-3642
Relation:	https://doi.org/10.1038/s42003-022-03696-z; https://doaj.org/toc/2399-3642; https://doaj.org/article/aaec8b98bed94ed097cfc4ed5a54e814
DOI:	10.1038/s42003-022-03696-z
الاتاحة:	https://doi.org/10.1038/s42003-022-03696-z https://doaj.org/article/aaec8b98bed94ed097cfc4ed5a54e814
رقم الانضمام:	edsbas.824F02DE
قاعدة البيانات:	BASE

الوصف
تدمد:	23993642
DOI:	10.1038/s42003-022-03696-z