Endogenous Dopamine Facilitates Striatalln Vivo Acetylcholine Release by Acting on D 1 Receptors Localized in the Striatum

التفاصيل البيبلوغرافية
العنوان:	Endogenous Dopamine Facilitates Striatalln Vivo Acetylcholine Release by Acting on D 1 Receptors Localized in the Striatum
المؤلفون:	Consolo, Silvana, Girotti, Prisca, Russi, Giovanni, Chiara, Gaetano Di
المصدر:	Journal of Neurochemistry ; volume 59, issue 4, page 1555-1557 ; ISSN 0022-3042 1471-4159
بيانات النشر:	Wiley
سنة النشر:	1992
المجموعة:	Wiley Online Library (Open Access Articles via Crossref)
الوصف:	Intrastriatal application of the D 1 antagonist SCH 23390 by two procedures, reverse dialysis (20 μ M ) and local injection (0.45 nmol per striatum), elicited a reduction in acetylcholine (ACh) release superimposable on that induced by systemic administration. The novel selective D 1 antagonist SCH 39166 produced a similar decreasing effect on striatal ACh release on local injection (0.45 nmol per striatum). On the other hand, local application of SCH 23390 into the frontal cortices (0.45 nmol per side) failed to alter striatal ACh overflow, indicating that the drug does not diffuse out of its injection site to any significant extent. The dopamine release inducer d ‐amphetamine (2 mg/kg s.c.) and the dopamine uptake inhibitor cocaine raised ACh release like the D 1 agonists. These effects were completely blocked by 10 μ M SCH 23390 applied by reverse dialysis. The results suggest that D 1 receptors regulating ACh release are located in the striatum.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1111/j.1471-4159.1992.tb08473.x
الاتاحة:	http://dx.doi.org/10.1111/j.1471-4159.1992.tb08473.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.1992.tb08473.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.1992.tb08473.x
Rights:	http://onlinelibrary.wiley.com/termsAndConditions#vor
رقم الانضمام:	edsbas.8244FD0C
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1111/j.1471-4159.1992.tb08473.x