التفاصيل البيبلوغرافية
| العنوان: |
Vasorelaxant Effect of Prunus mume (Siebold) Siebold & Zucc. Branch through the Endothelium-Dependent Pathway |
| المؤلفون: |
Cheolmin Jo, Bumjung Kim, Somin Lee, Inhye Ham, Kyungjin Lee, Ho-Young Choi |
| المصدر: |
Molecules; Volume 24; Issue 18; Pages: 3340 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
Prunus mume (Siebold) Siebold &, Zucc., vasorelaxation, endothelium-dependent, hypertension, cardiovascular disease, Korean plum |
| جغرافية الموضوع: |
agris |
| الوصف: |
Korean plum (Prunus mume (Siebold) Siebold & Zucc.) has long been used as a health food or herbal medicine in Asia. Previous studies have shown that several plants of the genus Prunus have vasodilatory and antihypertensive effects; we hypothesized that P. mume branches may have a vasorelaxant effect. In this study, we evaluated the effects and action mechanism of 70% ethanol extract of P. mume branch (PMB) on isolated rat aortic rings. Inhibitors such as NG-nitro-l-arginine methyl ester, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, methylene blue, indomethacin, atropine, tetraethylammonium chloride, glibenclamide, 4-aminopyridine and BaCl2 were used to investigate the mechanism of vasodilation responsible for the vascular relaxation. PMB (2–30 μg/mL) induced vasorelaxation in the presence of vascular endothelium, and all inhibitors used in this study affected the degree of relaxation. These results suggest that the vasorelaxant effect of PMB is endothelium-dependent and affects the nitric oxide-cyclic guanosine monophosphate pathway, prostacyclin pathway, muscarinic receptor pathway, and potassium channels. Our study explains that PMB may be another approach to hypertension treatment to reduce the burden of cardiovascular disease. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Natural Products Chemistry; https://dx.doi.org/10.3390/molecules24183340 |
| DOI: |
10.3390/molecules24183340 |
| الاتاحة: |
https://doi.org/10.3390/molecules24183340 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.82417B83 |
| قاعدة البيانات: |
BASE |