Academic Journal
π Bridge Engineering-Boosted Dual Enhancement of Type‑I Photodynamic and Photothermal Performance for Mitochondria-Targeting Multimodal Phototheranostics of Tumor
| العنوان: | π Bridge Engineering-Boosted Dual Enhancement of Type‑I Photodynamic and Photothermal Performance for Mitochondria-Targeting Multimodal Phototheranostics of Tumor |
|---|---|
| المؤلفون: | Laiping Fang, Qi Meng, Yuan Zhang, Rui Su, Fan Xing, Hualei Yang, Yuzhu Hou, Ping’an Ma, Keke Huang, Shouhua Feng |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Physiology, Pharmacology, Science Policy, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work subtly established, targeting phototheranostic agents, still remains challenging, simultaneously possess exceptional, reactive oxygen species, free intramolecular rotation, exhibited outstanding near, targeting multimodal phototheranostics, develop multifunctional ptas, boosted dual enhancement, π bridge engineering, tumor designing mitochondria, dual enhancement, π bridge, tumor cells, ptas ), multimodal imaging, π bridges, vivo <, vitro <, type ‑, photothermal therapy |
| الوصف: | Designing mitochondria-targeting phototheranostic agents (PTAs), which can simultaneously possess exceptional and balanced type-I photodynamic therapy (PDT) and photothermal therapy (PTT) performance, still remains challenging. Herein, benzene, furan, and thiophene were utilized as π bridges to develop multifunctional PTAs. STB with thiophene as a π bridge, in particular, benefiting from stronger donor–accepter (D–A) interactions, reduced the singlet–triplet energy gap (ΔE S1‑T1 ), allowed more free intramolecular rotation, and exhibited outstanding near-infrared (NIR) emission, effective type-I reactive oxygen species (ROS) generation, and relatively high photothermal conversion efficiency (PCE) of 51.9%. In vitro and in vivo experiments demonstrated that positive-charged STB not only can actively target the mitochondria of tumor cells but also displayed strong antitumor effects and excellent in vivo imaging ability. This work subtly established a win–win strategy by π bridge engineering, breaking the barrier of making a balance between ROS generation and photothermal conversion, boosting a dual enhancement of PDT and PTT performance, and stimulating the development of multimodal imaging-guided precise cancer phototherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/_Bridge_Engineering-Boosted_Dual_Enhancement_of_Type_I_Photodynamic_and_Photothermal_Performance_for_Mitochondria-Targeting_Multimodal_Phototheranostics_of_Tumor/24477193 |
| DOI: | 10.1021/acsnano.3c06542.s001 |
| الاتاحة: | https://doi.org/10.1021/acsnano.3c06542.s001 https://figshare.com/articles/journal_contribution/_Bridge_Engineering-Boosted_Dual_Enhancement_of_Type_I_Photodynamic_and_Photothermal_Performance_for_Mitochondria-Targeting_Multimodal_Phototheranostics_of_Tumor/24477193 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.81E5A38F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsnano.3c06542.s001 |
|---|