Academic Journal
Chronic Stress Produces Persistent Increases in Plasma Corticosterone, Reductions in Brain and Cardiac Nitric Oxide Production, and Delayed Alterations in Endothelial Function in Young Prehypertensive Rats
| العنوان: | Chronic Stress Produces Persistent Increases in Plasma Corticosterone, Reductions in Brain and Cardiac Nitric Oxide Production, and Delayed Alterations in Endothelial Function in Young Prehypertensive Rats |
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| المؤلفون: | Iveta Bernatova, Angelika Puzserova, Peter Balis, Natalia Sestakova, Martina Horvathova, Zuzana Kralovicova, Ingrid Zitnanova |
| المصدر: | Frontiers in Physiology, Vol 9 (2018) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | crowding stress, borderline hypertension, oxidative stress, corticosterone, nitric oxide, endothelial dysfunction, Physiology, QP1-981 |
| الوصف: | This study was designed to investigate whether oxidative stress, nitric oxide (NO) deficiency and/or endothelial dysfunction (ED) are present in young borderline hypertensive rats (BHR) and whether these pathologies can be causally involved in the initiation of blood pressure (BP) increases. Additionally, we tested the hypothesis that crowding stress, experienced during the peripubertal period, may produce persistent or delayed disorders in corticosterone release, NO synthesis, oxidative status and/or endothelial function that could accelerate BP increases. To test these hypotheses, 5-week-old male BHR and normotensive Wistar-Kyoto rats (WKY) were either kept in control conditions (for 2 and 4 weeks, respectively) or exposed to social stress produced by crowding for 2 weeks (stress). After cessation of crowding, a group of rats of each phenotype was kept in control conditions for the next 2 weeks (post-stress). Systolic BP of 5-week-old BHR was significantly increased vs. age-matched WKY (127 ± 3 vs. 104 ± 3 mmHg, p < 0.01) and remained significantly higher throughout the course of the experiment. Despite elevated BP, no signs of oxidative damage to plasma lipids, NO deficiency or ED were observed in control BHR vs. age-matched WKY. Crowding stress elevated plasma corticosterone and accelerated BP increases only in BHR; these effects persisted 2 weeks post-stress. Crowding failed to induce oxidative damage to plasma lipids in either phenotype, but it produced persistent decreases in NO production in the hypothalamus and brainstem of both strains of rats, as well as in the hearts of BHR. In contrast, crowding failed to reduce NO production in the aortae or acetylcholine-induced relaxations of the femoral arteries in both strains investigated. However, significantly reduced aortic NO production was observed in BHR 2 weeks post-stress vs. age-matched controls, which was in agreement with reduced NO-dependent components of vasorelaxation. In conclusion, this study’s data showed that oxidative stress, NO ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-042X |
| Relation: | https://www.frontiersin.org/article/10.3389/fphys.2018.01179/full; https://doaj.org/toc/1664-042X; https://doaj.org/article/d946b277fb10488380624503f5c2d2ea |
| DOI: | 10.3389/fphys.2018.01179 |
| الاتاحة: | https://doi.org/10.3389/fphys.2018.01179 https://doaj.org/article/d946b277fb10488380624503f5c2d2ea |
| رقم الانضمام: | edsbas.81C71CFB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1664042X |
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| DOI: | 10.3389/fphys.2018.01179 |