Academic Journal
Diagnosing atopic dermatitis in infancy using established diagnostic criteria: a cohort study
| العنوان: | Diagnosing atopic dermatitis in infancy using established diagnostic criteria: a cohort study |
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| المؤلفون: | Endre, K.M.A., Landrø, L., LeBlanc, M., Gjersvik, P., Lødrup Carlsen, K.C., Haugen, G., Hedlin, G., Jonassen, C.M., Nordlund, B., Rudi, K., Skjerven, H.O., Staff, A.C., Söderhäll, C., Vettukattil, R., Rehbinder, E.M. |
| المساهمون: | Freemason Child House Foundation in Stockholm, Arne Ingel’s bequest, SFO-V Karolinska Institutet, The Swedish Heart-Lung Foundation, The Regional Health Board South East, Stockholm County Council, the European Union, Norwegian Society of Dermatology and Venereology, the Kloster foundation, unrestricted grants from the Norwegian Association of Asthma and Allergy, The Foundation for Healthcare and Allergy Research in Sweden - Vårdalstiftelsen, the University of Oslo, Thermo Fisher, Swedish Asthma- and Allergy Association’s Research Foundation, Swedish Research Council - the Initiative for Clinical Therapy Research, Health and Rehabilitation Norway, Oslo University Hospital, The Norwegian Research Council, Østfold Hospital Trust |
| المصدر: | British Journal of Dermatology ; volume 186, issue 1, page 50-58 ; ISSN 1365-2133 0007-0963 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| الوصف: | Summary Background Diagnosing atopic dermatitis (AD) in infants is challenging. Objectives To determine the incidence and persistence of eczema and AD in infants using the UK Working Party (UKWP) and Hanifin and Rajka (H&R) criteria. Methods A cohort of 1834 infants was examined clinically at 3, 6 and 12 months of age. AD was diagnosed by UKWP (3, 6 and 12 months) and H&R (12 months) criteria. Logistic regression models were used to assess the relationship between AD and eczema. Results Eczema was observed in 628 (34·2%) infants (n = 240, n = 359 and n = 329 at 3, 6 and 12 months, respectively), with AD diagnosed in 212 (33·7%) infants with any eczema and in 64/78 (82%) infants with eczema at all three visits. The odds of AD were lower with first presentation of eczema at 6 [odds ratio (OR) 0·33, 95% confidence interval (CI) 0·22–0·48] or 12 months (OR 0·49, 95% CI 0·32–0·74) than at 3 months, and higher in infants with eczema at three (OR 23·1, 95% CI 12·3–43·6) or two (OR 6·5, 95% CI 4·3–9·9) visits vs. one visit only. At 12 months, 156/329 (47·4%) fulfilled the UKWP and/or H&R criteria; 27 (8%) fulfilled the UKWP criteria only and 65 (20%) only the H&R criteria. Of the 129 infants who fulfilled the H&R criteria, 44 (34·1%) did not meet the itch criterion. Conclusions Used in combination and at multiple timepoints, the UKWP and H&R criteria for AD may be useful in clinical research but may have limited value in most other clinical settings. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/bjd.19831 |
| الاتاحة: | http://dx.doi.org/10.1111/bjd.19831 https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjd.19831 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bjd.19831 https://academic.oup.com/bjd/article-pdf/186/1/50/47428321/bjd0050.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; http://doi.wiley.com/10.1002/tdm_license_1.1 |
| رقم الانضمام: | edsbas.817F00D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bjd.19831 |
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