Academic Journal
Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients
| العنوان: | Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients |
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| المؤلفون: | Kemmerer, Constanze L., Schittenhelm, Jens, Dubois, Evelyn, Neumann, Laura, Häsler, Lisa M., Lambert, Marius, Renovanz, Mirjam, Kaeser, Stephan A., Tabatabai, Ghazaleh, Ziemann, Ulf, Naumann, Ulrike, Kowarik, Markus |
| المصدر: | http://lobid.org/resources/99370673697106441#!, 21(1):1108. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Antigens, CD [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], CD163, Glioblastoma/pathology [MeSH], B cells, Receptors, Cell Surface [MeSH], Male [MeSH], Macrophages/cytology [MeSH], Tumor associated macrophages, Chemokine CCL11/cerebrospinal fluid [MeSH], Cytokines/cerebrospinal fluid [MeSH], Research Article, Glioblastoma/cerebrospinal fluid [MeSH], Female [MeSH], Immunohistochemistry, Differentiation, Myelomonocytic [MeSH], CD68, Adult [MeSH], Interleukins/cerebrospinal fluid [MeSH], Humans [MeSH], Astrocytoma/pathology [MeSH], Leukocytes/cytology [MeSH], Middle Aged [MeSH], Cytokines, Immunohistochemistry [MeSH] |
| الوصف: | Background!#!Diffuse gliomas are the most common malignant tumors of the central nervous system with poor treatment efficacy. Infiltration of immune cells into tumors during immunosurveillance is observed in multiple tumor entities and often associated with a favorable outcome. The aim of this study was to evaluate the infiltration of immune cells in gliomas and their association with cerebrospinal fluid (CSF) cytokine concentrations.!##!Methods!#!We applied immunohistochemistry in tumor tissue sections of 18 high-grade glioma (HGG) patients (4 anaplastic astrocytoma, IDH-wildtype WHO-III; 14 glioblastomas (GBM), IDH-wildtype WHO-IV) in order to assess and quantify leucocytes (CD45) and macrophages (CD68, CD163) within the tumor core, infiltration zone and perivascular spaces. In addition, we quantified the concentrations of 30 cytokines in the same patients' CSF and in 14 non-inflammatory controls.!##!Results!#!We observed a significantly higher percentage of CD68!##!Conclusions!#!Our findings suggest that the infiltration of lymphocytes is generally low in HGG, and does not correlate with cytokine concentrations in the CSF. In contrast, macrophage infiltrates in HGG are associated with CSF cytokine changes that possibly shape the tumor microenvironment. Although results point towards an escape from immunosurveillance or even exploitation of immune cells by HGG, further studies are necessary to decipher the exact role of the immune system in these tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6463191; https://doi.org/10.1186/s12885-021-08825-1; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520299/ |
| DOI: | 10.1186/s12885-021-08825-1 |
| الاتاحة: | https://repository.publisso.de/resource/frl:6463191 https://doi.org/10.1186/s12885-021-08825-1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520299/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.81335E47 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12885-021-08825-1 |
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