التفاصيل البيبلوغرافية
| العنوان: |
Generation of an induced pluripotent stem cell line from a healthy Caucasian male |
| المؤلفون: |
Martínez Moreno, Rebecca, Pérez Serra, Alexandra, Carreras, David, Aran Corbella, Begoña, Kuebler, Bernd, Brugada, Ramon, Scornik, Fabiana S., Pérez, Guillermo J., Selga i Coma, Elisabet |
| المصدر: |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2022 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Fibroblasts, Sistemes de control biològic, Biological control systems |
| الوصف: |
The effects of genetic mutations on protein function can be studied in a physiologically relevant environment using tissue-specific cells differentiated from patient-derived induced pluripotent stem cells (iPSC). However, it is crucial to use iPSC derived from healthy individuals as control. We generated an iPS cell line from skin fibroblasts of a healthy Caucasian male by nucleofection of non-integrating episomal vectors. This cell line has normal karyotype, expresses pluripotency surface markers and pluripotency genes, and successfully differentiates into cells of the 3 germ layers. Therefore, it can be used as control for any disease of interest that is modelled using iPSC. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
5 p.; application/pdf |
| اللغة: |
English |
| تدمد: |
1873-5061 |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.1016/j.scr.2022.102717; Stem Cell Research, 2022, vol. 60; https://doi.org/10.1016/j.scr.2022.102717; http://hdl.handle.net/2445/185901 |
| الاتاحة: |
http://hdl.handle.net/2445/185901 |
| Rights: |
cc by-nc-nd (c) Martínez Moreno, Rebecca et al, 2022 ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.812B642D |
| قاعدة البيانات: |
BASE |
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