Academic Journal
Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head
| العنوان: | Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head |
|---|---|
| المؤلفون: | Xiao, Fangjun, Wei, Tengfei, Xiao, Huan, He, Wei, Wei, Qiushi |
| المصدر: | Journal of Orthopaedic Surgery and Research ; volume 18, issue 1 ; ISSN 1749-799X |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Background Osteonecrosis of the femoral head (ONFH) is becoming a prevalent global health problem. 4-Hydroxynonenal (4-HNE) serves as a common marker of oxidative stress. This study aims to study the potential role of 4-HNE in the progression of steroid-induced osteonecrosis of the femoral head (SIONFH). Method Between April 2021 and December 2021, 64 subjects were enrolled in this cross-sectional case‒control study. Thirty-six patients were grouped based on the Association Research Circulation Osseous (ARCO) classification, and 28 healthy volunteers without hip pain or any lesions shown in anteroposterior and frog-leg lateral pelvic radiographs served as the normal control group. Bone hematoxylin–eosin (HE) staining, microcomputed tomography (micro-CT), immunohistochemistry, and levels of plasma 4-HNE were evaluated. Results The 4-HNE level was higher in the SIONFH group than in the normal control group ( P < 0.001), and 4-HNE levels were significantly higher in SIONFH patients in the early stage of disease (stage II). The 4-HNE level was negatively correlated with ARCO stage ( r = − 0.6875, P < 0.001). Immunohistochemistry revealed the presence of 4-HNE in the trabecular bone, osteocytes, and bone marrow. Conclusion The 4-HNE level is negatively associated with ARCO stages. Lower levels of 4-HNE may serve as a critical biomarker for the progression of SIONFH. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s13018-023-04153-1 |
| DOI: | 10.1186/s13018-023-04153-1.pdf |
| DOI: | 10.1186/s13018-023-04153-1/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s13018-023-04153-1 https://link.springer.com/content/pdf/10.1186/s13018-023-04153-1.pdf https://link.springer.com/article/10.1186/s13018-023-04153-1/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.811100C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13018-023-04153-1 |
|---|