Academic Journal
Neurotensin is increased in serum of young children with autistic disorder
| العنوان: | Neurotensin is increased in serum of young children with autistic disorder |
|---|---|
| المؤلفون: | Angelidou Asimenia, Francis Konstantinos, Vasiadi Magdalini, Alysandratos Konstantinos-Dionysios, Zhang Bodi, Theoharides Athanasios, Lykouras Lefteris, Sideri Kyriaki, Kalogeromitros Dimitrios, Theoharides Theoharis C |
| المصدر: | Journal of Neuroinflammation, Vol 7, Iss 1, p 48 (2010) |
| بيانات النشر: | BMC |
| سنة النشر: | 2010 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Autism spectrum disorders (ASD) are a group of pervasive neurodevelopmental disorders diagnosed in early childhood. They are associated with a set of "core symptoms" that include disabilities in social interaction skills, verbal and non-verbal communication, as well as repetitive and stereotypic behaviors. There is no definite pathogenetic mechanism or diagnostic tests. Many children with ASD also have "allergic-like" symptoms, but test negative implying mast cell activation by non-allergic triggers. We measured by Milliplex arrays serum levels of 3 neuropeptides that could stimulate mast cells in children with autistic disorder (n = 19; 16 males and 3 females; mean age 3.0 ± 0.4 years) and healthy, unrelated controls (n = 16; 13 males and 3 females; mean age 3 ± 1.2 years). Only neurotensin (NT) was significantly increased from 60.5 ± 6.0 pg/ml in controls to 105.6 ± 12.4 pg/ml in autistic disorder (p = 0.004). There was no statistically significant difference in the serum levels of β-endorphin or substance P (SP). NT could stimulate immune cells, especially mast cells, and/or have direct effects on brain inflammation and ASD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1742-2094 |
| Relation: | http://www.jneuroinflammation.com/content/7/1/48; https://doaj.org/toc/1742-2094; https://doaj.org/article/9660df3d3b684271afc3ec85b8c5ff23 |
| DOI: | 10.1186/1742-2094-7-48 |
| الاتاحة: | https://doi.org/10.1186/1742-2094-7-48 https://doaj.org/article/9660df3d3b684271afc3ec85b8c5ff23 |
| رقم الانضمام: | edsbas.80EE03EB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17422094 |
|---|---|
| DOI: | 10.1186/1742-2094-7-48 |